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SALL4 Expression in Hepatocellular Carcinomas Is Associated with EpCAM-Positivity and a Poor Prognosis
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2018-03-26T16:52:34Z | - |
dc.date.available | 2018-03-26T16:52:34Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156906 | - |
dc.description.abstract | BACKGROUND: There is increasing interest in hepatocellular carcinomas (HCC) expressing "stemness"-related markers, as they have been associated with aggressive behavior and poor prognosis. In this study, we investigated the usefulness of Sal-like protein 4 (SALL4), a recently proposed candidate marker of "stemness." METHODS: Immunohistochemical stains were performed for SALL4, K19, and epithelial cellular adhesion molecule (EpCAM) on tissue microarrays constructed from 190 surgically resected HCCs, and the results were correlated with the clinicopathological features and patient survival data. RESULTS: Nuclear SALL4 expression was observed in 39/190 HCCs (20.5%), while K19 and EpCAM were expressed in 30 (15.9%) and 92 (48.7%) HCCs, respectively. The nuclear expression was generally weak, punctate or clumped. SALL4 expression was significantly associated with a poor overall survival compared to SALL4-negative HCCs (p = .014) compared to SALL4-negative HCCs. On multivariate analysis adjusted for tumor size, multiplicity, vascular invasion, and pathological tumor stage, SALL4 remained as a significant independent predictor of decreased overall survival (p= .004). SALL4 expression was positively correlated with EpCAM expression (p = .013) but not with K19 expression. HCCs that expressed both SALL4 and EpCAM were associated with significantly decreased overall survival, compared to those cases which were negative for both of these markers (p = .031). CONCLUSIONS: Although SALL4 expression was not significantly correlated with other clinicopathological parameters suggestive of tumor aggressiveness, SALL4 expression was an independent predictor of poor overall survival in human HCCs, and was also positively correlated with EpCAM expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | The Korean Society of Pathologists | - |
dc.relation.isPartOf | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | SALL4 Expression in Hepatocellular Carcinomas Is Associated with EpCAM-Positivity and a Poor Prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Hyunjin Park | - |
dc.contributor.googleauthor | Hyejung Lee | - |
dc.contributor.googleauthor | An Na Seo | - |
dc.contributor.googleauthor | Jai Young Cho | - |
dc.contributor.googleauthor | Young Rok Choi | - |
dc.contributor.googleauthor | Yoo-Seok Yoon | - |
dc.contributor.googleauthor | Ho-Seong Han | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Haeryoung Kim | - |
dc.identifier.doi | 10.4132/jptm.2015.07.09 | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J01680 | - |
dc.identifier.eissn | 2383-7845 | - |
dc.identifier.pmid | 26265684 | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | hepatocellular | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | SALL4 | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.citation.volume | 49 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 373 | - |
dc.citation.endPage | 381 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.49(5) : 373-381, 2015 | - |
dc.identifier.rimsid | 41215 | - |
dc.type.rims | ART | - |
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