Cited 7 times in
Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium
DC Field | Value | Language |
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dc.contributor.author | 김성헌 | - |
dc.contributor.author | 노경진 | - |
dc.contributor.author | 문인석 | - |
dc.contributor.author | 정진세 | - |
dc.contributor.author | 최재영 | - |
dc.date.accessioned | 2018-03-26T16:52:17Z | - |
dc.date.available | 2018-03-26T16:52:17Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156898 | - |
dc.description.abstract | The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and balance function. Many ion channels, transporters, and exchangers have been identified in the ES luminal epithelium, mainly in animal studies, but there has been no functional study investigating ion transport using human ES tissue. We designed the first functional experiments on electrogenic transport in human ES and investigated the contribution of K(+) channels in the electrogenic transport, which has been rarely identified, even in animal studies, using electrophysiological/pharmacological and molecular biological methods. As a result, we identified functional and molecular evidence for the essential participation of K(+) channels in the electrogenic transport of human ES epithelium. The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Chromatography, Liquid | - |
dc.subject.MESH | Cochlea/metabolism | - |
dc.subject.MESH | Cochlea/physiology | - |
dc.subject.MESH | Electrophysiological Phenomena | - |
dc.subject.MESH | Endolymphatic Sac/metabolism | - |
dc.subject.MESH | Endolymphatic Sac/physiology* | - |
dc.subject.MESH | Epithelium/metabolism | - |
dc.subject.MESH | Epithelium/physiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Ion Transport/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Potassium/metabolism* | - |
dc.subject.MESH | Potassium Channels/genetics | - |
dc.subject.MESH | Potassium Channels/metabolism | - |
dc.subject.MESH | Potassium Channels/physiology* | - |
dc.subject.MESH | Potassium Channels, Tandem Pore Domain/genetics | - |
dc.subject.MESH | Potassium Channels, Tandem Pore Domain/metabolism | - |
dc.subject.MESH | Potassium Channels, Tandem Pore Domain/physiology | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Small-Conductance Calcium-Activated Potassium Channels/genetics | - |
dc.subject.MESH | Small-Conductance Calcium-Activated Potassium Channels/metabolism | - |
dc.subject.MESH | Small-Conductance Calcium-Activated Potassium Channels/physiology | - |
dc.subject.MESH | Tandem Mass Spectrometry | - |
dc.title | Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | Sung Huhn Kim | - |
dc.contributor.googleauthor | Bo Gyung Kim | - |
dc.contributor.googleauthor | Jin Young Kim | - |
dc.contributor.googleauthor | Kyung Jin Roh | - |
dc.contributor.googleauthor | Michelle J. Suh | - |
dc.contributor.googleauthor | Jin Sei Jung | - |
dc.contributor.googleauthor | In Seok Moon | - |
dc.contributor.googleauthor | Sung K. Moon | - |
dc.contributor.googleauthor | Jae Young Choi | - |
dc.identifier.doi | 10.1038/srep18110 | - |
dc.contributor.localId | A00589 | - |
dc.contributor.localId | A04560 | - |
dc.contributor.localId | A01374 | - |
dc.contributor.localId | A03742 | - |
dc.contributor.localId | A04173 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 26655723 | - |
dc.contributor.alternativeName | Kim, Sung Huhn | - |
dc.contributor.alternativeName | Roh, Kyung Jin | - |
dc.contributor.alternativeName | Moon, In Seok | - |
dc.contributor.alternativeName | Jung, Jinsei | - |
dc.contributor.alternativeName | Choi, Jae Young | - |
dc.contributor.affiliatedAuthor | Kim, Sung Huhn | - |
dc.contributor.affiliatedAuthor | Roh, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Moon, In Seok | - |
dc.contributor.affiliatedAuthor | Jung, Jinsei | - |
dc.contributor.affiliatedAuthor | Choi, Jae Young | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 18110 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.5 : 18110, 2015 | - |
dc.identifier.rimsid | 41207 | - |
dc.type.rims | ART | - |
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