Cited 3 times in
MTB-DR-RIF 9G test: Detection and discrimination of tuberculosis and multi-drug resistant tuberculosis strains
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2018-03-26T16:51:37Z | - |
dc.date.available | 2018-03-26T16:51:37Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1472-9792 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156883 | - |
dc.description.abstract | This report describes the evaluation of the novel MTB-DR-RIF 9G test for the accurate detection and discrimination of Mycobacterium tuberculosis (MTB) and rifampicin-resistant M. tuberculosis (MTB-DR-RIF) in the clinical samples. The procedure included the amplification of a nucleotide fragment of the rpoB gene of the MTB and MTB-DR-RIF strains and their hybridization with the immobilized probes. The MTB-DR-RIF 9G test was evaluated for its ability to detect and discriminate MTB and MTB-DR-RIF strains in 113 known clinical samples. The accuracy of the MTB-DR-RIF 9G test was determined by comparing its results with sequencing analysis and drug susceptibility testing. The sensitivity and specificity of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 95.4% (89.5-98.5) and 100% (69.2-100), respectively. The positive predictive value and negative predictive value of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 100% (85.0-95.9) and 66.7% (38.4-88.18), respectively. Sequencing analysis of all samples indicated that the mutations present in the regions identified with the MTB-DR-RIF 9G assay can be detected accurately. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Churchill Livingstone | - |
dc.relation.isPartOf | TUBERCULOSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antibiotics, Antitubercular/therapeutic use* | - |
dc.subject.MESH | Bacterial Proteins/genetics* | - |
dc.subject.MESH | Bacteriological Techniques* | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | DNA, Bacterial/genetics* | - |
dc.subject.MESH | DNA-Directed RNA Polymerases/genetics* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Discriminant Analysis | - |
dc.subject.MESH | Drug Resistance, Multiple, Bacterial/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Molecular Diagnostic Techniques* | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects | - |
dc.subject.MESH | Mycobacterium tuberculosis/genetics* | - |
dc.subject.MESH | Nucleic Acid Hybridization | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Rifampin/therapeutic use* | - |
dc.subject.MESH | Tuberculosis/diagnosis* | - |
dc.subject.MESH | Tuberculosis/drug therapy | - |
dc.subject.MESH | Tuberculosis/microbiology | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/diagnosis* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/drug therapy | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/microbiology | - |
dc.title | MTB-DR-RIF 9G test: Detection and discrimination of tuberculosis and multi-drug resistant tuberculosis strains | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Keum-Soo Song | - |
dc.contributor.googleauthor | Satish Balasaheb Nimse | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Nackmoon Sung | - |
dc.contributor.googleauthor | Hee-jin Kim | - |
dc.contributor.googleauthor | Jeongseong Yang | - |
dc.contributor.googleauthor | Taisun Kim | - |
dc.identifier.doi | 10.1016/j.tube.2015.08.008 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J02760 | - |
dc.identifier.eissn | 1873-281X | - |
dc.identifier.pmid | 26381057 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1472979215301335 | - |
dc.subject.keyword | Accuracy | - |
dc.subject.keyword | Diagnosis | - |
dc.subject.keyword | Drug resistant tuberculosis | - |
dc.subject.keyword | Sensitivity | - |
dc.subject.keyword | Specificity | - |
dc.subject.keyword | Tuberculosis | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.citation.volume | 95 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 780 | - |
dc.citation.endPage | 785 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS, Vol.95(6) : 780-785, 2015 | - |
dc.identifier.rimsid | 41192 | - |
dc.type.rims | ART | - |
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