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Effects of Prophylactic Antiepileptic Drugs on Clinical Outcomes in Patients with a Good Clinical Grade Suffering from Aneurysmal Subarachnoid Hemorrhage
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.contributor.author | 윤선진 | - |
dc.contributor.author | 정준호 | - |
dc.contributor.author | 주진양 | - |
dc.contributor.author | 홍창기 | - |
dc.date.accessioned | 2018-03-26T16:50:54Z | - |
dc.date.available | 2018-03-26T16:50:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2234-8565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156873 | - |
dc.description.abstract | OBJECTIVE: Routine use of prophylactic antiepileptic drugs (AED) has been debated. We retrospectively evaluated the effects of prophylactic AED on clinical outcomes in patients with a good clinical grade suffering from aneurysmal subarachnoid hemorrhage (aSAH). MATERIALS AND METHODS: Between September 2012 and December 2014, 84 patients who met the following criteria were included: (1) presence of a ruptured aneurysm; (2) Hunt-Hess grade 1, 2, or 3; and (3) without seizure presentation. Patients were divided into two groups; the AED group (n = 44) and the no AED group (n = 40). Clinical data and outcomes were compared between the two groups. RESULTS: Prophylactic AEDs were used more frequently in patients who underwent microsurgery (84.1%) compared to those who underwent endovascular surgery (15.9%, p < 0.001). Regardless of prophylactic AED use, seizure episodes were not observed during the six-month follow-up period. No statistical difference in clinical outcomes at discharge (p = 0.607) and after six months of follow-up (p = 0.178) were between the two groups. After six months, however, favorable outcomes in the no AED group tended to increase and poor outcomes tended to decrease. CONCLUSION: No difference in the clinical outcomes and systemic complications at discharge and after six months of follow-up was observed between the two groups. However, favorable outcomes in the no AED group showed a slight increase after six months. These findings suggest that discontinuation of the current practice of using prophylactic AED might be recommended in patients with a good clinical grade. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society of Cerebrovascular Surgeons | - |
dc.relation.isPartOf | Journal of Cerebrovascular and Endovascular Neurosurgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of Prophylactic Antiepileptic Drugs on Clinical Outcomes in Patients with a Good Clinical Grade Suffering from Aneurysmal Subarachnoid Hemorrhage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Seon Jin Yoon | - |
dc.contributor.googleauthor | Jin-Yang Joo | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Chang-Ki Hong | - |
dc.contributor.googleauthor | Joonho Chung | - |
dc.identifier.doi | 10.7461/jcen.2015.17.3.166 | - |
dc.contributor.localId | A00743 | - |
dc.contributor.localId | A05256 | - |
dc.contributor.localId | A03731 | - |
dc.contributor.localId | A03959 | - |
dc.contributor.localId | A04445 | - |
dc.relation.journalcode | J01307 | - |
dc.identifier.eissn | 2287-3139 | - |
dc.identifier.pmid | 26526008 | - |
dc.subject.keyword | Antiepileptic drug | - |
dc.subject.keyword | Clinical outcome | - |
dc.subject.keyword | Intracranial aneurysm | - |
dc.subject.keyword | Seizure | - |
dc.subject.keyword | Subarachnoid hemorrhage | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Yoon, Seon Jin | - |
dc.contributor.alternativeName | Chung, Joon Ho | - |
dc.contributor.alternativeName | Joo, Jin Yang | - |
dc.contributor.alternativeName | Hong, Chang Ki | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Yoon, Seon Jin | - |
dc.contributor.affiliatedAuthor | Chung, Joon Ho | - |
dc.contributor.affiliatedAuthor | Joo, Jin Yang | - |
dc.contributor.affiliatedAuthor | Hong, Chang Ki | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 166 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | Journal of Cerebrovascular and Endovascular Neurosurgery, Vol.17(3) : 166-172, 2015 | - |
dc.identifier.rimsid | 40001 | - |
dc.type.rims | ART | - |
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