222 552

Cited 0 times in

Effects of Prophylactic Antiepileptic Drugs on Clinical Outcomes in Patients with a Good Clinical Grade Suffering from Aneurysmal Subarachnoid Hemorrhage

DC Field Value Language
dc.contributor.author김용배-
dc.contributor.author윤선진-
dc.contributor.author정준호-
dc.contributor.author주진양-
dc.contributor.author홍창기-
dc.date.accessioned2018-03-26T16:50:54Z-
dc.date.available2018-03-26T16:50:54Z-
dc.date.issued2015-
dc.identifier.issn2234-8565-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156873-
dc.description.abstractOBJECTIVE: Routine use of prophylactic antiepileptic drugs (AED) has been debated. We retrospectively evaluated the effects of prophylactic AED on clinical outcomes in patients with a good clinical grade suffering from aneurysmal subarachnoid hemorrhage (aSAH). MATERIALS AND METHODS: Between September 2012 and December 2014, 84 patients who met the following criteria were included: (1) presence of a ruptured aneurysm; (2) Hunt-Hess grade 1, 2, or 3; and (3) without seizure presentation. Patients were divided into two groups; the AED group (n = 44) and the no AED group (n = 40). Clinical data and outcomes were compared between the two groups. RESULTS: Prophylactic AEDs were used more frequently in patients who underwent microsurgery (84.1%) compared to those who underwent endovascular surgery (15.9%, p < 0.001). Regardless of prophylactic AED use, seizure episodes were not observed during the six-month follow-up period. No statistical difference in clinical outcomes at discharge (p = 0.607) and after six months of follow-up (p = 0.178) were between the two groups. After six months, however, favorable outcomes in the no AED group tended to increase and poor outcomes tended to decrease. CONCLUSION: No difference in the clinical outcomes and systemic complications at discharge and after six months of follow-up was observed between the two groups. However, favorable outcomes in the no AED group showed a slight increase after six months. These findings suggest that discontinuation of the current practice of using prophylactic AED might be recommended in patients with a good clinical grade.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Cerebrovascular Surgeons-
dc.relation.isPartOfJournal of Cerebrovascular and Endovascular Neurosurgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Prophylactic Antiepileptic Drugs on Clinical Outcomes in Patients with a Good Clinical Grade Suffering from Aneurysmal Subarachnoid Hemorrhage-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorSeon Jin Yoon-
dc.contributor.googleauthorJin-Yang Joo-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorChang-Ki Hong-
dc.contributor.googleauthorJoonho Chung-
dc.identifier.doi10.7461/jcen.2015.17.3.166-
dc.contributor.localIdA00743-
dc.contributor.localIdA05256-
dc.contributor.localIdA03731-
dc.contributor.localIdA03959-
dc.contributor.localIdA04445-
dc.relation.journalcodeJ01307-
dc.identifier.eissn2287-3139-
dc.identifier.pmid26526008-
dc.subject.keywordAntiepileptic drug-
dc.subject.keywordClinical outcome-
dc.subject.keywordIntracranial aneurysm-
dc.subject.keywordSeizure-
dc.subject.keywordSubarachnoid hemorrhage-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameYoon, Seon Jin-
dc.contributor.alternativeNameChung, Joon Ho-
dc.contributor.alternativeNameJoo, Jin Yang-
dc.contributor.alternativeNameHong, Chang Ki-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorYoon, Seon Jin-
dc.contributor.affiliatedAuthorChung, Joon Ho-
dc.contributor.affiliatedAuthorJoo, Jin Yang-
dc.contributor.affiliatedAuthorHong, Chang Ki-
dc.citation.volume17-
dc.citation.number3-
dc.citation.startPage166-
dc.citation.endPage172-
dc.identifier.bibliographicCitationJournal of Cerebrovascular and Endovascular Neurosurgery, Vol.17(3) : 166-172, 2015-
dc.identifier.rimsid40001-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.