110 387

Cited 0 times in

Prognostic Factors of Gamma Knife Radiosurgery for Cerebral Arteriovenous Malformation : The Results from 218 Consecutive Patients

DC Field Value Language
dc.contributor.author김덕영-
dc.contributor.author박근영-
dc.contributor.author박용구-
dc.contributor.author이재환-
dc.contributor.author장원석-
dc.contributor.author장종희-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.contributor.author허승곤-
dc.date.accessioned2018-03-26T16:50:36Z-
dc.date.available2018-03-26T16:50:36Z-
dc.date.issued2015-
dc.identifier.issn1738-6217-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156870-
dc.description.abstract"Objective: We retrospectively evaluated our experience of the management and long-term outcomes of gamma knife radiosurgery (GKRS) on arteriovenous malformation (AVM) as a primary treatment as well as adjunct therapy. GKRS is widely used in many centers worldwide for the management of AVM. However, the long-term results of GKRS are not well known. In the present study, we retrospectively evaluated our experience of focusing on prognostic factors in the management and long-term outcomes of GKRS on AVM. Materials and Methods: We performed a retrospective review of 218 patients. They were treated with GKRS in our institute from 2007 to 2013. The group included first-time GKRS for cerebral AVM, previous surgical resection, and embolization, excluding previously GKRS-treated patients. We analyzed the association between several factors (gender, age, marginal dose, hemorrhage, marginal dose, nidus volume) and the obliteration rate, which was the cumulative obliteration rate regardless of additional treatment, including repeat GKRS. Results: The univariate analysis of our study identified that a high radiation dose [margin dose >16.0Gy (50%), p=0.017] rather than a low radiation dose [margin dose ≤16.0Gy (50%)] and small AVM volume (≤15.0mL, p=0.003) rather than large AVM volume (>15.0mL) were positive predictors of AVM nidus obliteration. Our study showed that young age (≤18 years) had a better obliteration rate compared with others (>18 years) in AVM after GKRS (p=0.053). Our findings did not show that gender (p= 0.427) or hemorrhage (p=0.191) had significant effects on nidus obliteration. Comparison of our results with prior studies showed that AVM volume and margin radiation dose had a significant role in the obliteration rate in common. Conclusion: We suggest that AVM with a small volume can be considered good indications for GKRS, and a higher marginal dose [margin dose >16.0Gy (50%)] can be an effective factor for higher obliteration with the carefulness of post-radiosurgical complications. Finally, we can expect favorable GKRS results for appropriately selected AVMs in the young population."-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한정위기능신경외과학회-
dc.relation.isPartOfJournal of the Korean Society of Stereotactic and Functional Neurosurgery (대한정위기능신경외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrognostic Factors of Gamma Knife Radiosurgery for Cerebral Arteriovenous Malformation : The Results from 218 Consecutive Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorDeok Young Kim-
dc.contributor.googleauthorKeun Young Park-
dc.contributor.googleauthorJae Whan Lee-
dc.contributor.googleauthorSeung Kon Huh-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorJin Woo Chang-
dc.contributor.googleauthorYong Gou Park-
dc.contributor.googleauthorWon Seok Chang-
dc.contributor.localIdA04818-
dc.contributor.localIdA01442-
dc.contributor.localIdA01578-
dc.contributor.localIdA03088-
dc.contributor.localIdA03454-
dc.contributor.localIdA03470-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.contributor.localIdA04356-
dc.relation.journalcodeJ01891-
dc.subject.keywordArteriovenous malformation(AVM)-
dc.subject.keywordGamma knife radiosurgery(GKRS)-
dc.subject.keywordObliteration rate-
dc.subject.keywordPrognostic factors-
dc.contributor.alternativeNameKim, Deok Young-
dc.contributor.alternativeNamePark, Keun Young-
dc.contributor.alternativeNamePark, Yong Gou-
dc.contributor.alternativeNameLee, Jae Whan-
dc.contributor.alternativeNameChang, Won Seok-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.alternativeNameHuh, Seung Kon-
dc.contributor.affiliatedAuthorKim, Deok Young-
dc.contributor.affiliatedAuthorPark, Keun Young-
dc.contributor.affiliatedAuthorPark, Yong Gou-
dc.contributor.affiliatedAuthorLee, Jae Whan-
dc.contributor.affiliatedAuthorChang, Won Seok-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.contributor.affiliatedAuthorHuh, Seung Kon-
dc.citation.volume11-
dc.citation.startPage106-
dc.citation.endPage111-
dc.identifier.bibliographicCitationJournal of the Korean Society of Stereotactic and Functional Neurosurgery (대한정위기능신경외과학회지), Vol.11 : 106-111, 2015-
dc.identifier.rimsid39998-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.