Cited 33 times in
Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고윤우 | - |
dc.contributor.author | 김원식 | - |
dc.contributor.author | 김현주 | - |
dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 서영욱 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 이기영 | - |
dc.contributor.author | 이보라 | - |
dc.contributor.author | 주형민 | - |
dc.date.accessioned | 2018-03-26T16:48:44Z | - |
dc.date.available | 2018-03-26T16:48:44Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156844 | - |
dc.description.abstract | BACKGROUND: Adequate neuromuscular block is required throughout laryngeal microsurgery. We hypothesized that the surgical conditions would improve under a deeper level of rocuronium-induced neuromuscular block. METHODS: Seventy-two patients undergoing laryngeal microsurgery were randomly allocated to either the 'post-tetanic counts 1-2' (PTC1-2) group or the 'train-of-four counts 1-2' (TOFcount1-2) group according to the level of neuromuscular block used. Two different doses of rocuronium (1.2 or 0.5 mg kg(-1)) were used after anaesthetic induction, and two respective targets of neuromuscular block (post-tetanic counts ≤2 or train-of-four count of 1 or 2) were used. Surgical conditions were assessed by the surgeon using a five-point rating scale (extremely poor/poor/acceptable/good/optimal), and clinically acceptable surgical conditions were defined as those which were rated acceptable, good, or optimal. The occurrence of vocal cord movement and postoperative adverse events was assessed. RESULTS: The surgical conditions were significantly different between the PTC1-2 and TOFcount1-2 groups (extremely poor/poor/acceptable/good/optimal: 0/2/1/7/26 and 3/10/2/14/7, respectively, P<0.001). The incidence of clinically acceptable surgical conditions was significantly higher in the PTC1-2 group than in the TOFcount1-2 group (94 vs 64%, P=0.003). The percentage of patients who exhibited vocal cord movement was significantly lower in the PTC1-2 group than in the TOFcount1-2 group (3 vs 39%, P<0.001). The incidence of postoperative adverse events was not significantly different except for the less frequent occurrence of mouth dryness in the PTC1-2 group (P=0.035). CONCLUSIONS: Deep neuromuscular block (post-tetanic count of 1-2) surgical conditions in patients undergoing laryngeal microsurgery improves. CLINICAL TRIAL REGISTRATION: NCT01980069. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Androstanols/administration & dosage* | - |
dc.subject.MESH | Anesthesia, General/methods | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Larynx/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsurgery/adverse effects | - |
dc.subject.MESH | Microsurgery/methods* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monitoring, Intraoperative/methods | - |
dc.subject.MESH | Neuromuscular Blockade/methods* | - |
dc.subject.MESH | Neuromuscular Junction/drug effects | - |
dc.subject.MESH | Neuromuscular Junction/physiopathology | - |
dc.subject.MESH | Neuromuscular Nondepolarizing Agents/administration & dosage* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | H. J. Kim | - |
dc.contributor.googleauthor | K. Lee | - |
dc.contributor.googleauthor | W. K. Park | - |
dc.contributor.googleauthor | B. R. Lee | - |
dc.contributor.googleauthor | H. M. Joo | - |
dc.contributor.googleauthor | Y. W. Koh | - |
dc.contributor.googleauthor | Y. W. Seo | - |
dc.contributor.googleauthor | W. S. Kim | - |
dc.contributor.googleauthor | Y. C. Yoo | - |
dc.identifier.doi | 10.1093/bja/aev368 | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A00765 | - |
dc.contributor.localId | A01135 | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A04757 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A02695 | - |
dc.contributor.localId | A02803 | - |
dc.contributor.localId | A04800 | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 26582847 | - |
dc.subject.keyword | larynx | - |
dc.subject.keyword | neuromuscular blockade | - |
dc.subject.keyword | neuromuscular monitoring | - |
dc.contributor.alternativeName | Kho, Yoon Woo | - |
dc.contributor.alternativeName | Kim, Won Shik | - |
dc.contributor.alternativeName | Kim, Hyun Zu | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Seo, Young Wook | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.alternativeName | Lee, Ki Young | - |
dc.contributor.alternativeName | Lee, Bo Ra | - |
dc.contributor.alternativeName | Joo, Hyung Min | - |
dc.contributor.affiliatedAuthor | Kho, Yoon Woo | - |
dc.contributor.affiliatedAuthor | Kim, Won Shik | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Joo | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Seo, Young Wook | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Lee, Ki Young | - |
dc.contributor.affiliatedAuthor | Lee, Bo Ra | - |
dc.contributor.affiliatedAuthor | Joo, Hyung Min | - |
dc.citation.volume | 115 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 867 | - |
dc.citation.endPage | 872 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.115(6) : 867-872, 2015 | - |
dc.identifier.rimsid | 39972 | - |
dc.type.rims | ART | - |
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