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Cited 11 times in

Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery

DC FieldValueLanguage
dc.contributor.author고윤우-
dc.contributor.author김원식-
dc.contributor.author김현주-
dc.contributor.author박윤곤-
dc.contributor.author서영욱-
dc.contributor.author유영철-
dc.contributor.author이기영-
dc.contributor.author이보라-
dc.contributor.author주형민-
dc.date.accessioned2018-03-26T16:48:44Z-
dc.date.available2018-03-26T16:48:44Z-
dc.date.issued2015-
dc.identifier.issn0007-0912-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156844-
dc.description.abstractBACKGROUND: Adequate neuromuscular block is required throughout laryngeal microsurgery. We hypothesized that the surgical conditions would improve under a deeper level of rocuronium-induced neuromuscular block. METHODS: Seventy-two patients undergoing laryngeal microsurgery were randomly allocated to either the 'post-tetanic counts 1-2' (PTC1-2) group or the 'train-of-four counts 1-2' (TOFcount1-2) group according to the level of neuromuscular block used. Two different doses of rocuronium (1.2 or 0.5 mg kg(-1)) were used after anaesthetic induction, and two respective targets of neuromuscular block (post-tetanic counts ≤2 or train-of-four count of 1 or 2) were used. Surgical conditions were assessed by the surgeon using a five-point rating scale (extremely poor/poor/acceptable/good/optimal), and clinically acceptable surgical conditions were defined as those which were rated acceptable, good, or optimal. The occurrence of vocal cord movement and postoperative adverse events was assessed. RESULTS: The surgical conditions were significantly different between the PTC1-2 and TOFcount1-2 groups (extremely poor/poor/acceptable/good/optimal: 0/2/1/7/26 and 3/10/2/14/7, respectively, P<0.001). The incidence of clinically acceptable surgical conditions was significantly higher in the PTC1-2 group than in the TOFcount1-2 group (94 vs 64%, P=0.003). The percentage of patients who exhibited vocal cord movement was significantly lower in the PTC1-2 group than in the TOFcount1-2 group (3 vs 39%, P<0.001). The incidence of postoperative adverse events was not significantly different except for the less frequent occurrence of mouth dryness in the PTC1-2 group (P=0.035). CONCLUSIONS: Deep neuromuscular block (post-tetanic count of 1-2) surgical conditions in patients undergoing laryngeal microsurgery improves. CLINICAL TRIAL REGISTRATION: NCT01980069.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfBritish Journal of Anaesthesia-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAndrostanols/administration & dosage*-
dc.subject.MESHAnesthesia, General/methods-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLarynx/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMicrosurgery/adverse effects-
dc.subject.MESHMicrosurgery/methods*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonitoring, Intraoperative/methods-
dc.subject.MESHNeuromuscular Blockade/methods*-
dc.subject.MESHNeuromuscular Junction/drug effects-
dc.subject.MESHNeuromuscular Junction/physiopathology-
dc.subject.MESHNeuromuscular Nondepolarizing Agents/administration & dosage*-
dc.subject.MESHProspective Studies-
dc.subject.MESHYoung Adult-
dc.titleDeep neuromuscular block improves the surgical conditions for laryngeal microsurgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorH. J. Kim-
dc.contributor.googleauthorK. Lee-
dc.contributor.googleauthorW. K. Park-
dc.contributor.googleauthorB. R. Lee-
dc.contributor.googleauthorH. M. Joo-
dc.contributor.googleauthorY. W. Koh-
dc.contributor.googleauthorY. W. Seo-
dc.contributor.googleauthorW. S. Kim-
dc.contributor.googleauthorY. C. Yoo-
dc.identifier.doi10.1093/bja/aev368-
dc.contributor.localIdA00133-
dc.contributor.localIdA00765-
dc.contributor.localIdA01135-
dc.contributor.localIdA01593-
dc.contributor.localIdA04757-
dc.contributor.localIdA02484-
dc.contributor.localIdA02695-
dc.contributor.localIdA02803-
dc.contributor.localIdA04800-
dc.relation.journalcodeJ00405-
dc.identifier.eissn1471-6771-
dc.identifier.pmid26582847-
dc.subject.keywordlarynx-
dc.subject.keywordneuromuscular blockade-
dc.subject.keywordneuromuscular monitoring-
dc.contributor.alternativeNameKho, Yoon Woo-
dc.contributor.alternativeNameKim, Won Shik-
dc.contributor.alternativeNameKim, Hyun Zu-
dc.contributor.alternativeNamePark, Wyun Kon-
dc.contributor.alternativeNameSeo, Young Wook-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.alternativeNameLee, Ki Young-
dc.contributor.alternativeNameLee, Bo Ra-
dc.contributor.alternativeNameJoo, Hyung Min-
dc.contributor.affiliatedAuthorKho, Yoon Woo-
dc.contributor.affiliatedAuthorKim, Won Shik-
dc.contributor.affiliatedAuthorKim, Hyun Joo-
dc.contributor.affiliatedAuthorPark, Wyun Kon-
dc.contributor.affiliatedAuthorSeo, Young Wook-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.contributor.affiliatedAuthorLee, Ki Young-
dc.contributor.affiliatedAuthorLee, Bo Ra-
dc.contributor.affiliatedAuthorJoo, Hyung Min-
dc.citation.volume115-
dc.citation.number6-
dc.citation.startPage867-
dc.citation.endPage872-
dc.identifier.bibliographicCitationBritish Journal of Anaesthesia, Vol.115(6) : 867-872, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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