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Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author남궁기-
dc.date.accessioned2018-03-26T16:48:23Z-
dc.date.available2018-03-26T16:48:23Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156835-
dc.description.abstractOxytocin receptor gene single nucleotide polymorphisms have been associated with structural and functional alterations in brain regions, which involve social-emotional processing. Therefore, oxytocin receptor gene polymorphisms may contribute to individual differences in alexithymia, which is considered to be a dysfunction of emotional processing. The aim of this study was to evaluate the association between oxytocin receptor gene single nucleotide polymorphisms or haplotypes and alexithymia in patients with obsessive-compulsive disorder. We recruited 355 patients with obsessive-compulsive disorder (234 men, 121 women). Alexithymia was measured by using the Toronto Alexithymia Scale. We performed single-marker and haplotype association analyses with eight single nucleotide polymorphisms (rs237885, rs237887, rs2268490, rs4686301, rs2254298, rs13316193, rs53576, and rs2268498) in the oxytocin receptor gene. There were no significant associations between any of the eight single nucleotide polymorphism of the oxytocin receptor gene and alexithymia. In addition, a six-locus haplotype block (rs237885-rs237887-rs2268490-rs4686301-rs2254298-rs13316193) was not significantly associated with alexithymia. These findings suggest that genetic variations in the oxytocin receptor gene may not explain a significant part of alexithymia in patients with obsessive-compulsive disorder.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAffective Symptoms/complications*-
dc.subject.MESHAffective Symptoms/genetics*-
dc.subject.MESHDemography-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Association Studies*-
dc.subject.MESHGenetic Predisposition to Disease*-
dc.subject.MESHHaplotypes/genetics-
dc.subject.MESHHumans-
dc.subject.MESHLinkage Disequilibrium/genetics-
dc.subject.MESHMale-
dc.subject.MESHObsessive-Compulsive Disorder/complications-
dc.subject.MESHObsessive-Compulsive Disorder/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide/genetics*-
dc.subject.MESHQuantitative Trait Loci/genetics-
dc.subject.MESHReceptors, Oxytocin/genetics*-
dc.titleLack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorMin Jung Koh-
dc.contributor.googleauthorWonji Kim-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.1371/journal.pone.0143168-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid26599592-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.citation.volume10-
dc.citation.number11-
dc.citation.startPagee0143168-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(11) : e0143168, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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