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Effects of Previous or Synchronous Non-Muscle Invasive Bladder Cancer on Clinical Results after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Multi-Institutional Study
DC Field | Value | Language |
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dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2018-03-26T16:48:10Z | - |
dc.date.available | 2018-03-26T16:48:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1735-1308 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156829 | - |
dc.description.abstract | PURPOSE: To evaluate the effects of the presence of previous or synchronous non-muscle invasive bladder cancer (NMIBC) on the oncologic outcomes of radical nephroureterectomy in patients with upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathologic parameters of patients with and without previous or synchronous NMIBC were compared, and Kaplan-Meier estimates and multivariate Cox regression analyses were performed. RESULTS: The median follow-up period was 38.4 months. In all, 408 patients had primary UTUC, 45 (8.9%) had a history of NMIBC, 59 (11.7%) had concomitant bladder cancer, and seven (1.4%) had experienced both. Tumors in patients with associated NMIBC were more commonly multifocal (P = .001) and associated with surgical margin positivity (P = .001). Kaplan-Meier estimates revealed that previous or synchronous NMIBC was significantly associated with bladder recurrence (P < .001) and locoregional recurrence/distant metastasis (P = .008). A multivariate Cox regression model identified previous or synchronous NMIBC as an independent predictor of bladder recurrence (P < .001). However, the presence of previous or synchronous NMIBC was not a prognostic indicator of locoregional recurrence/distant metastasis. CONCLUSION: In patients with UTUC, previous or synchronous NMIBC was significantly associated with an increased risk of cancer recurrences in the bladder after radical nephroureterectomy. The present findings suggest that a close monitoring should be required for the patients with previous or concomitant NMIBC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Urology and Nephrology Research Center | - |
dc.relation.isPartOf | UROLOGY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Transitional Cell/mortality | - |
dc.subject.MESH | Carcinoma, Transitional Cell/pathology | - |
dc.subject.MESH | Carcinoma, Transitional Cell/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Recurrence, Local/epidemiology | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neoplasms, Multiple Primary* | - |
dc.subject.MESH | Nephrectomy/methods* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Ureter/surgery* | - |
dc.subject.MESH | Ureteral Neoplasms/pathology | - |
dc.subject.MESH | Ureteral Neoplasms/surgery* | - |
dc.subject.MESH | Urinary Bladder/pathology* | - |
dc.subject.MESH | Urinary Bladder Neoplasms/mortality | - |
dc.subject.MESH | Urinary Bladder Neoplasms/pathology | - |
dc.subject.MESH | Urinary Bladder Neoplasms/surgery* | - |
dc.title | Effects of Previous or Synchronous Non-Muscle Invasive Bladder Cancer on Clinical Results after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Multi-Institutional Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Bup Wan Kim | - |
dc.contributor.googleauthor | Yun-Sok Ha | - |
dc.contributor.googleauthor | Jun Nyung Lee | - |
dc.contributor.googleauthor | Hyun Tae Kim | - |
dc.contributor.googleauthor | Tae-Hwan Kim | - |
dc.contributor.googleauthor | Jung Keun Lee | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Ho Won Kang | - |
dc.contributor.googleauthor | Seok-Joong Yun | - |
dc.contributor.googleauthor | Wun-Jae Kim | - |
dc.contributor.googleauthor | Young Suk Kwon | - |
dc.contributor.googleauthor | Tae Gyun Kwon | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02940 | - |
dc.identifier.eissn | 1735-546X | - |
dc.identifier.pmid | 26341764 | - |
dc.identifier.url | https://search.proquest.com/docview/1717423055?accountid=15179 | - |
dc.subject.keyword | neoplasm recurrence | - |
dc.subject.keyword | nephrectomy | - |
dc.subject.keyword | urinary bladder neoplasms | - |
dc.subject.keyword | treatment outcome | - |
dc.subject.keyword | urologic surgical procedures | - |
dc.subject.keyword | urothelium | - |
dc.subject.keyword | pathology | - |
dc.subject.keyword | urologic neoplasms | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2233 | - |
dc.citation.endPage | 2239 | - |
dc.identifier.bibliographicCitation | UROLOGY JOURNAL, Vol.12(4) : 2233-2239, 2015 | - |
dc.identifier.rimsid | 39957 | - |
dc.type.rims | ART | - |
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