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Acceleration of Bone Regeneration by BMP-2-Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus

Authors
 Jung-Soo Kim  ;  Jae-Kook Cha  ;  Ah-Ran Cho  ;  Min-Soo Kim  ;  Jung-Seok Lee  ;  Ji-Youn Hong  ;  Seong-Ho Choi  ;  Ui-Won Jung 
Citation
 CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Vol.17(6) : 1103-1113, 2015 
Journal Title
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
ISSN
 1523-0899 
Issue Date
2015
MeSH
Absorbable Implants ; Animals ; Bone Morphogenetic Proteins/pharmacology* ; Bone Regeneration/drug effects* ; Collagen/pharmacology* ; Hydroxyapatites/pharmacology* ; Imaging, Three-Dimensional ; Male ; Nasal Mucosa/drug effects ; Rabbits ; Random Allocation ; Sinus Floor Augmentation/methods* ; Surgical Flaps ; Wound Healing/physiology ; X-Ray Microtomography
Keywords
bone substitutes ; bone tissue engineering ; bone regeneration ; sinus augmentation
Abstract
PURPOSE: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus.

MATERIAL AND METHODS: In 16 rabbits, BMP-2-loaded CBCP was grafted into one sinus (the BMP group) and saline-soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks (n = 8) or 4 weeks (n = 8), radiographic and histological analysis was performed.

RESULTS: Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group.

CONCLUSION: It can be concluded that the addition of BMP-2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/cid.12223/abstract
DOI
10.1111/cid.12223
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156810
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