Cited 8 times in
Therapeutic plasma exchange using the Spectra Optia cell separator compared with the COBE Spectra
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.contributor.author | 김신영 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2018-03-26T16:42:48Z | - |
dc.date.available | 2018-03-26T16:42:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156742 | - |
dc.description.abstract | BACKGROUND: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety. METHODS: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed. RESULTS: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was 94.2±10.3 min in the SPO group and 100.4±11.2 min in the CSP group (P<0.001). The plasma removal efficiency (PRE) was 92.5±4.9% in the SPO group and 83.2±3.7% in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters. CONCLUSIONS: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Component Removal/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft Rejection/prevention & control | - |
dc.subject.MESH | Hematocrit | - |
dc.subject.MESH | Hemoglobins/analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation | - |
dc.subject.MESH | Leukocyte Count | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Plasma Exchange* | - |
dc.subject.MESH | Platelet Count | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Therapeutic plasma exchange using the Spectra Optia cell separator compared with the COBE Spectra | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Do-kyun Kim | - |
dc.contributor.googleauthor | Sinyoung Kim | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Hyun Ok Kim | - |
dc.contributor.googleauthor | Hyung Jik Kim | - |
dc.identifier.doi | 10.3343/alm.2015.35.5.506 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A00675 | - |
dc.contributor.localId | A01122 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.identifier.pmid | 26206687 | - |
dc.subject.keyword | Apheresis | - |
dc.subject.keyword | Efficacy | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Plasma exchange | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.alternativeName | Kim, Sin Young | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | Kim, Sin Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ok | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 506 | - |
dc.citation.endPage | 509 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.35(5) : 506-509, 2015 | - |
dc.identifier.rimsid | 39872 | - |
dc.type.rims | ART | - |
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