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Engineered microstructure granules for tailored drug release rate

Authors
 Min-Ho Hong  ;  Heon-Jin Choi  ;  Yeong-Mu Ko  ;  Yong-Keun Lee 
Citation
 BIOTECHNOLOGY AND BIOENGINEERING, Vol.112(9) : 1936-1947, 2015 
Journal Title
 BIOTECHNOLOGY AND BIOENGINEERING 
ISSN
 0006-3592 
Issue Date
2015
MeSH
Animals ; Biocompatible Materials/chemistry* ; Biocompatible Materials/pharmacology ; Cell Proliferation/drug effects ; Cells, Cultured ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacology ; Dexamethasone/chemistry* ; Dexamethasone/pharmacokinetics ; Dexamethasone/pharmacology ; Drug Carriers/chemistry* ; Durapatite/chemistry* ; Durapatite/pharmacology ; Lactic Acid/chemistry* ; Mice ; Osteogenesis/drug effects ; Polyglycolic Acid/chemistry* ; Tissue Engineering/methods*
Keywords
EDC/NHS chemistry ; bone tissue engineering ; controlled drug release ; dexamethasone ; hydroxyapatite ; microstructure
Abstract
Biomaterials developed for controlled drug delivery have demonstrated excellent results in the present study. A biomaterial prepared using hydroxyapatite (HAp) was shown to have a hollow structure with the presence of interconnected pores to house drug carriers. The poly(lactic-co-glycolic acid) particles were used as drug carriers loaded with dexamethasone, a corticosteroid that is known to promote osteoinduction. The surface of the drug carriers was modified using polyethyleneimine, and then conjugated to the surface of HAp granules. The hollow HAp granules had drug carriers on both their inner and outer surfaces and showed a controlled drug release rate that was comparable to that of granules containing drug carriers on their outer surface alone. The pores were designed for insertion of drug carriers and preosteoblasts. Consequently, the biomaterials influenced cellular behavior by first promoting cell proliferation and then inducing early stage osteogenic differentiation. The effects of controlled release rate were evidenced for up to two weeks after cell seeding, resulting in an increase of osteogenic differentiation. In summary, drug carriers loaded onto hollow HAp granules were shown to be suitable for patients who require replacement of missing bone for repair of bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/bit.25595/abstract
DOI
10.1002/bit.25595
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Hong, Min Ho(홍민호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156687
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