Cited 106 times in
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.date.accessioned | 2018-01-23T05:54:02Z | - |
dc.date.available | 2018-01-23T05:54:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/155794 | - |
dc.description.abstract | Regulatory enhancer elements in solid tumours remain poorly characterized. Here we apply micro-scale chromatin profiling to survey the distal enhancer landscape of primary gastric adenocarcinoma (GC), a leading cause of global cancer mortality. Integrating 110 epigenomic profiles from primary GCs, normal gastric tissues and cell lines, we highlight 36,973 predicted enhancers and 3,759 predicted super-enhancers respectively. Cell-line-defined super-enhancers can be subclassified by their somatic alteration status into somatic gain, loss and unaltered categories, each displaying distinct epigenetic, transcriptional and pathway enrichments. Somatic gain super-enhancers are associated with complex chromatin interaction profiles, expression patterns correlated with patient outcome and dense co-occupancy of the transcription factors CDX2 and HNF4α. Somatic super-enhancers are also enriched in genetic risk SNPs associated with cancer predisposition. Our results reveal a genome-wide reprogramming of the GC enhancer and super-enhancer landscape during tumorigenesis, contributing to dysregulated local and regional cancer gene expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Wen Fong Ooi | - |
dc.contributor.googleauthor | Manjie Xing | - |
dc.contributor.googleauthor | Chang Xu | - |
dc.contributor.googleauthor | Xiaosai Yao | - |
dc.contributor.googleauthor | Muhammad Khairul Ramlee | - |
dc.contributor.googleauthor | Mei Chee Lim | - |
dc.contributor.googleauthor | Fan Cao | - |
dc.contributor.googleauthor | Kevin Lim | - |
dc.contributor.googleauthor | Deepak Babu | - |
dc.contributor.googleauthor | Lai-Fong Poon | - |
dc.contributor.googleauthor | Joyce Lin Suling | - |
dc.contributor.googleauthor | Aditi Qamra | - |
dc.contributor.googleauthor | Astrid Irwanto | - |
dc.contributor.googleauthor | James Qu Zhengzhong | - |
dc.contributor.googleauthor | Tannistha Nandi | - |
dc.contributor.googleauthor | Ai Ping Lee-Lim | - |
dc.contributor.googleauthor | Yang Sun Chan | - |
dc.contributor.googleauthor | Su Ting Tay | - |
dc.contributor.googleauthor | Ming Hui Lee | - |
dc.contributor.googleauthor | James O.J. Davies | - |
dc.contributor.googleauthor | Wai Keong Wong | - |
dc.contributor.googleauthor | Khee Chee Soo | - |
dc.contributor.googleauthor | Weng Hoong Chan | - |
dc.contributor.googleauthor | Hock Soo Ong | - |
dc.contributor.googleauthor | Pierce Chow | - |
dc.contributor.googleauthor | Chow Yin Wong | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Jianjun Liu | - |
dc.contributor.googleauthor | Axel M. Hillmer | - |
dc.contributor.googleauthor | Jim R. Hughes | - |
dc.contributor.googleauthor | Steve Rozen | - |
dc.contributor.googleauthor | Bin Tean Teh | - |
dc.contributor.googleauthor | Melissa Jane Fullwood | - |
dc.contributor.googleauthor | Shang Li | - |
dc.contributor.googleauthor | Patrick Tan | - |
dc.contributor.googleauthor | Regulatory enhancer | - |
dc.identifier.doi | 10.1038/ncomms12983 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 27677335 | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 12983 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.7 : 12983, 2016 | - |
dc.identifier.rimsid | 48824 | - |
dc.type.rims | ART | - |
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