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Chiral Biomaterials: From Molecular Design to Regenerative Medicine

Authors
 David W. Green  ;  Jong-Min Lee  ;  Eun-Jung Kim  ;  Dong-Joon Lee  ;  Han-Sung Jung 
Citation
 ADVANCED MATERIALS INTERFACES, Vol.3(6) : 1500411, 2016 
Journal Title
ADVANCED MATERIALS INTERFACES
Issue Date
2016
Abstract
Chirality is integral to biological complexity. Chiral biomolecules are central to all fundamental recognition, conformational and replication functions in biological systems. Chirality also exists in living cells and higher order biological structures. Less is known about the cellular interactions with chirality, although most living cells are imprinted with chiral-based signatures. The harnessing of molecular, supramolecular, and structural chirality has been largely overlooked in biomaterials chemistry and the engineering of biological structures for regenerative medicine. Since chirality is a fundamental element of biological architecture its implementation in materials biomimicry is a necessity for mechanical, structural, and biological reasons. Take the latter, new investigations show the direct influence of biomimetic chiral patterning and chiral-based architecture on stem cell activities and behavior. Biomimetic integration of chirality signatures into medical biomaterials provides a new capability to maximize biological function and compatibility especially for morphogenesis and regeneration.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/admi.201500411/abstract
DOI
10.1002/admi.201500411
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
David, William Green(데이비드 그린)
Lee, Dong Joon(이동준) ORCID logo https://orcid.org/0000-0001-6532-9729
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/155786
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