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ALK-rearranged adenocarcinoma with extensive mucin production can mimic mucinous adenocarcinoma: clinicopathological analysis and comprehensive histological comparison with KRAS-mutated mucinous adenocarcinoma

DC FieldValueLanguage
dc.contributor.author차윤진-
dc.date.accessioned2018-01-23T05:53:12Z-
dc.date.available2018-01-23T05:53:12Z-
dc.date.issued2016-
dc.identifier.issn0031-3025-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155775-
dc.description.abstractWe aimed to investigate clinicopathological features and histology of ALK-rearranged adenocarcinomas with extensive mucin production (AEM) that mimic mucinous adenocarcinoma (MA). Retrospectively, 12 cases of AEM and 25 cases of MA harbouring KRAS mutation were retrieved. The clinicopathological profile and detailed histological features were analysed and compared based on the ALK and KRAS status. AEMs occurred in younger patients (p = 0.044) and were characterised by floating tubulopapillary pattern (p < 0.001), prominent nucleolus (p < 0.001), and apical cytoplasmic snouts (p < 0.001). In contrast, KRAS-mutated MAs lacked ALK-specific histological patterns (p < 0.05). Instead, tumour-infiltrating leukocytes (p = 0.018) and smooth cytoplasmic borders (p < 0.001) with vesicular nuclei (p = 0.004) were prominent in KRAS-mutated MAs. AEMs demonstrated characteristic tubulopapillary pattern and apical snouts, which were distinguishing features from MAs with KRAS mutation. Apical snouts can be a useful histological surrogate for ALK rearrangement in the pulmonary adenocarcinomas showing extensive mucin that mimic MA.-
dc.description.statementOfResponsibilityrestriction-
dc.relation.isPartOfPATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleALK-rearranged adenocarcinoma with extensive mucin production can mimic mucinous adenocarcinoma: clinicopathological analysis and comprehensive histological comparison with KRAS-mutated mucinous adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorYOON JIN CHA-
dc.contributor.googleauthorJOUNGHO HAN-
dc.contributor.googleauthorSOO HYUN HWANG-
dc.contributor.googleauthorTAE BUM LEE-
dc.contributor.googleauthorHOJOONG KIM-
dc.contributor.googleauthorJEA ILL ZO-
dc.identifier.doi10.1016/j.pathol.2016.02.016-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ02471-
dc.identifier.eissn1465-3931-
dc.identifier.pmid27114375-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0031302516324904-
dc.contributor.alternativeNameCha, Yoon Jin-
dc.contributor.affiliatedAuthorCha, Yoon Jin-
dc.citation.volume48-
dc.citation.number4-
dc.citation.startPage325-
dc.citation.endPage329-
dc.identifier.bibliographicCitationPATHOLOGY, Vol.48(4) : 325-329, 2016-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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