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Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury

DC Field Value Language
dc.contributor.author임범진-
dc.date.accessioned2018-01-23T05:52:19Z-
dc.date.available2018-01-23T05:52:19Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155749-
dc.description.abstractDapagliflozin, a new type of drug used to treat diabetes mellitus (DM), is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Although some studies showed that SGLT2 inhibition attenuated reactive oxygen generation in diabetic kidney the role of SGLT2 inhibition is unknown. We evaluated whether SLT2 inhibition has renoprotective effects in ischemia-reperfusion (IR) models. We evaluated whether dapagliflozin reduces renal damage in IR mice model. In addition, hypoxic HK2 cells were treated with or without SGLT2 inhibitor to investigate cell survival, the apoptosis signal pathway, and the induction of hypoxia-inducible factor 1 (HIF1) and associated proteins. Dapagliflozin improved renal function. Dapagliflozin reduced renal expression of Bax, renal tubule injury and TUNEL-positive cells and increased renal expression of HIF1 in IR-injured mice. HIF1 inhibition by albendazole negated the renoprotective effects of dapagliflozin treatment in IR-injured mice. In vitro, dapagliflozin increased the expression of HIF1, AMP-activated protein kinase (AMPK), and ERK and increased cell survival of hypoxic HK2 cells in a dose-dependent manner. In conclusion, dapagliflozin attenuates renal IR injury. HIF1 induction by dapagliflozin may play a role in renoprotection against renal IR injury.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAMP-Activated Protein Kinases/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHBenzhydryl Compounds/pharmacology*-
dc.subject.MESHCell Hypoxia/drug effects-
dc.subject.MESHCell Line-
dc.subject.MESHDiabetic Nephropathies/drug therapy-
dc.subject.MESHDiabetic Nephropathies/metabolism-
dc.subject.MESHDiabetic Nephropathies/pathology-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases/metabolism-
dc.subject.MESHGlucosides/pharmacology*-
dc.subject.MESHHypoxia-Inducible Factor 1/metabolism-
dc.subject.MESHKidney Diseases/drug therapy*-
dc.subject.MESHKidney Diseases/metabolism-
dc.subject.MESHKidney Diseases/pathology-
dc.subject.MESHKidney Tubules, Proximal/metabolism-
dc.subject.MESHKidney Tubules, Proximal/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHReperfusion Injury/drug therapy*-
dc.subject.MESHReperfusion Injury/metabolism-
dc.subject.MESHReperfusion Injury/pathology-
dc.subject.MESHSodium-Glucose Transporter 2/antagonists & inhibitors*-
dc.subject.MESHbcl-2-Associated X Protein/metabolism-
dc.titleDapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorYoon-Kyung Chang-
dc.contributor.googleauthorHyunsu Choi-
dc.contributor.googleauthorJin Young Jeong-
dc.contributor.googleauthorKi-Ryang Na-
dc.contributor.googleauthorKang Wook Lee-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorDae Eun Choi-
dc.identifier.doi10.1371/journal.pone.0158810-
dc.contributor.localIdA03363-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27391020-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.citation.volume11-
dc.citation.number7-
dc.citation.startPagee0158810-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(7) : e0158810, 2016-
dc.identifier.rimsid48203-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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