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A multicenter analysis of adjuvant therapy after surgery for stage IIIC endometrial adenocarcinoma: A Korean Radiation Oncology Group study (KROG 13-17)
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.contributor.author | 차지혜 | - |
dc.date.accessioned | 2018-01-23T05:51:15Z | - |
dc.date.available | 2018-01-23T05:51:15Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/155720 | - |
dc.description.abstract | OBJECTIVE: To investigate whether combined chemoradiotherapy (CTRT) confers a benefit for survival outcome over radiotherapy (RT) alone after primary surgery in patients with FIGO stage IIIC endometrial adenocarcinoma. METHODS: We conducted a multicenter retrospective study of patients with surgical stage IIIC endometrial cancer from 1990 to 2011. Adjuvant RT alone was performed in 85 patients (40.3%) and adjuvant CTRT in 126 patients (59.7%). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. RESULTS: Stage IIIC1 and stage IIIC2 accounted for 63% and 37%, respectively. FIGO IIIC2 had a higher recurrence rate than FIGO IIIC1 (38.5% vs. 29.3%, p=0.172). Five-year OS and DFS were lower in FIGO IIIC2 than FIGO IIIC1 (85.1% vs. 76.9%, p=0.417; 71.0% vs. 59.2%, p=0.108, respectively). Eighteen patients (13.5%) in stage IIIC1 developed PALN recurrence, whereas only one (3.3%) in stage IIIC2 had PALN recurrence (p=0.001). In multivariate analysis, predictors of DFS were parametrial invasion (HR, 3.49; 95% CI, 1.83-6.64; p<0.001), higher grade (HR, 2.78; 95% CI, 1.31-5.89; p=0.008), and >3 positive pelvic nodes (HR, 1.84; 95% CI, 1.11-3.05; p=0.019). Combined CTRT did not affect DFS or OS in IIIC1 and IIIC2 compared with RT alone. CONCLUSION: CTRT showed comparable survival outcome to RT alone. Half of relapses (46%) in stage IIIC1 occurred in PALN region, whereas relapse in stage IIIC2 primarily occurred in distant metastasis (90%). Future randomized studies are needed to determine which subgroup may be most likely to benefit from CCRT. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/drug therapy* | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/radiotherapy* | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Endometrial Neoplasms/drug therapy* | - |
dc.subject.MESH | Endometrial Neoplasms/pathology | - |
dc.subject.MESH | Endometrial Neoplasms/radiotherapy* | - |
dc.subject.MESH | Endometrial Neoplasms/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | A multicenter analysis of adjuvant therapy after surgery for stage IIIC endometrial adenocarcinoma: A Korean Radiation Oncology Group study (KROG 13-17) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Mee Sun Yoon | - |
dc.contributor.googleauthor | Won Park | - |
dc.contributor.googleauthor | Seung Jae Huh | - |
dc.contributor.googleauthor | Hak Jae Kim | - |
dc.contributor.googleauthor | Young Seok Kim | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Joo-Young Kim | - |
dc.contributor.googleauthor | Jong-Hoon Lee | - |
dc.contributor.googleauthor | Hun Jung Kim | - |
dc.contributor.googleauthor | Jihye Cha | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Juree Kim | - |
dc.contributor.googleauthor | Won Sup Yoon | - |
dc.contributor.googleauthor | Jin Hwa Choi | - |
dc.contributor.googleauthor | Mison Chun | - |
dc.contributor.googleauthor | Youngmin Choi | - |
dc.contributor.googleauthor | Sei Kyung Chang | - |
dc.contributor.googleauthor | Kang Kyoo Lee | - |
dc.contributor.googleauthor | Myungsoo Kim | - |
dc.identifier.doi | 10.1016/j.ygyno.2015.06.030 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A04009 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 26115977 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0090825815300494 | - |
dc.subject.keyword | Adjuvant chemoradiotherapy | - |
dc.subject.keyword | Adjuvant radiotherapy | - |
dc.subject.keyword | Endometrial cancer | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Cha, Ji Hye | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Cha, Ji Hye | - |
dc.citation.volume | 138 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 519 | - |
dc.citation.endPage | 525 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.138(3) : 519-525, 2015 | - |
dc.identifier.rimsid | 48179 | - |
dc.type.rims | ART | - |
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