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Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process

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dc.contributor.author김용훈-
dc.contributor.author김지현-
dc.contributor.author김현기-
dc.contributor.author김호근-
dc.contributor.author박재준-
dc.contributor.author박준철-
dc.contributor.author박효진-
dc.contributor.author신성관-
dc.contributor.author윤영훈-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author정다현-
dc.contributor.author정현수-
dc.date.accessioned2018-01-23T05:50:38Z-
dc.date.available2018-01-23T05:50:38Z-
dc.date.issued2015-
dc.identifier.issn2093-582X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155707-
dc.description.abstractPURPOSE: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. MATERIALS AND METHODS: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age- and sex-matched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. RESULTS: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Open-type atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). CONCLUSIONS: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF GASTRIC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHelicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorHyun Soo Chung-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorYong Hoon Kim-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.5230/jgc.2015.15.4.246-
dc.contributor.localIdA00756-
dc.contributor.localIdA00996-
dc.contributor.localIdA01108-
dc.contributor.localIdA01183-
dc.contributor.localIdA01636-
dc.contributor.localIdA01676-
dc.contributor.localIdA01774-
dc.contributor.localIdA02112-
dc.contributor.localIdA02583-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03591-
dc.contributor.localIdA03765-
dc.relation.journalcodeJ01415-
dc.identifier.eissn2093-5641-
dc.identifier.pmid26819804-
dc.subject.keywordEndoscopic resection-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordMetachronous-
dc.subject.keywordStomach neoplasms-
dc.contributor.alternativeNameKim, Yong Hoon-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameJung, Da Hyun-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.affiliatedAuthorKim, Yong Hoon-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorJung, Da Hyun-
dc.contributor.affiliatedAuthorChung, Hyun Soo-
dc.citation.volume15-
dc.citation.number4-
dc.citation.startPage246-
dc.citation.endPage255-
dc.identifier.bibliographicCitationJOURNAL OF GASTRIC CANCER, Vol.15(4) : 246-255, 2015-
dc.identifier.rimsid48166-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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