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Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss

Authors
 Si-Hyung Lee MD  ;  Zhenlong Zheng MD, PhD  ;  Jin-Soo Kang MD  ;  Do-Young Kim MD  ;  Sang Ho Oh MD, PhD  ;  Sung Bin Cho MD, PhD Si-Hyung Lee MD  ;  Sung Bin Cho MD, PhD  ;  Si-Hyung Lee  ;  Zhenlong Zheng  ;  Jin-Soo Kang  ;  Do-Young Kim  ;  Sang Ho Oh  ;  Sung Bin Cho 
Citation
 WOUND REPAIR AND REGENERATION, Vol.23 : 30-36, 2015 
Journal Title
 WOUND REPAIR AND REGENERATION 
ISSN
 1067-1927 
Issue Date
2015
MeSH
Adult ; Alopecia/drug therapy ; Alopecia/pathology ; Alopecia/therapy* ; Animals ; Cell Proliferation/drug effects* ; Female ; Hair/drug effects ; Hair/growth & development* ; Hair Follicle/drug effects ; Hair Follicle/growth & development* ; Humans ; Injections ; Male ; Middle Aged ; Platelet-Rich Plasma*/metabolism ; Polydeoxyribonucleotides/administration & dosage* ; Polydeoxyribonucleotides/pharmacology ; Proto-Oncogene Proteins/metabolism ; Rabbits ; Regenerative Medicine ; Republic of Korea ; Scalp/drug effects ; Scalp/growth & development* ; Scalp/pathology ; Up-Regulation ; Wnt Proteins/metabolism ; Wnt-5a Protein
Abstract
Autologous platelet-rich plasma (PRP) exerts positive therapeutic effects on hair thickness and density in patients with pattern hair loss. The aim of our study was to evaluate the efficacy of intra-perifollicular autologous PRP and polydeoxyribonucleotide (PDRN) injections in treating female pattern hair loss (FPHL). Twenty FPHL patients were treated with a single session of PRP injection, followed by 12 sessions of PDRN intra-perifollicular injection, along the scalp at weekly intervals. Additionally, another 20 FPHL patients were treated with 12 sessions of PDRN injection only. Meanwhile, one half of the backs of two rabbits was injected with the PRP preparation, while the other half was injected with phosphate buffered saline as a control. Tissue samples from the rabbits were analyzed by real-time polymerase chain reaction and Western blotting. Compared with baseline values, patients treated with PRP and PDRN injections exhibited clinical improvement in mean hair counts (23.2 ± 15.5%; p < 0.001) and mean hair thickness (16.8 ± 10.8%; p < 0.001). In addition, patients treated with the 12 sessions of intra-perifollicular PDRN injection alone also showed clinical improvement in mean hair counts (17.9 ± 13.2%; p < 0.001) and mean hair thickness (13.5 ± 10.7%; p < 0.001). Comparison analyses between the two groups revealed that combined therapy with PRP and PDRN induces greater improvement in hair thickness than treatment with PDRN therapy alone (p = 0.031), but not in hair counts (p > 0.05). The pilot animal study revealed significant up-regulation of WNT, platelet-derived growth factor, and fibroblast growth factor expression in rabbit skin treated with the PRP preparation, compared with control skin. In conclusion, intra-perifollicular injections of autologous PRP and/or PDRN generate improvements in hair thickness and density in FPHL patients.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/wrr.12250/abstract
DOI
10.1111/wrr.12250
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Si Hyung(이시형)
Cho, Sung Bin(조성빈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/155676
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