Cited 20 times in
Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 이준호 | - |
dc.date.accessioned | 2018-01-23T05:49:02Z | - |
dc.date.available | 2018-01-23T05:49:02Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1602-1622 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/155668 | - |
dc.description.abstract | OBJECTIVE: To evaluate the association between the concentrations of immune-related proteins in mid-trimester amniotic fluid (AF) and the subsequent risk of spontaneous preterm delivery in twins. STUDY DESIGN: The study population consisted of consecutive women with a twin pregnancy who underwent clinically indicated genetic amniocentesis at 15 to 20 weeks, and had a subsequent spontaneous delivery in the early preterm period (<32 weeks (cases)) or at term (37 to 42 weeks (controls)). AF was analyzed for cytokines (interleukin (IL)-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13 and IL-15, interferon-γ, tumor necrosis factor-α), matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-12), and chemokines (complement factor-D/Adipsin, Serpin E1/PAI-1, Adiponectin/Acrp30, C-Reactive Protein, CCL2/MCP-1, Leptin, Resistin) using multiplex immunoassay kits. The association between AF protein levels and subsequent early preterm birth were examined. RESULT: A total of 96 sets of twins were enrolled, including 17 early preterm birth cases and 79 term controls. AF concentrations of IL-6, IL-8, MMP-3, MMP-8 and MMP-9, and CCL2/MCP-1 were significantly higher in cases than controls. Among these analytes, the combination of AF IL-8 and MMP-9 values had the highest predictive value for early preterm birth. The risk was 8% (10/132) for IL-8<1200 pg ml(-1) and MMP-9<1000 pg ml(-1), 30% (15/50) for IL-8>1200 pg ml(-1) or MMP-9>1000 pg ml(-1), and 90% (9/10) for IL-8>1200 pg ml(-1) and MMP-9>1000 pg ml(-1) (P<0.001). CONCLUSION: High concentrations of IL-8 and MMP-9 in mid-trimester AF in twins predicted well the risk of early preterm birth. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | ORAL HEALTH & PREVENTIVE DENTISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Amniocentesis/methods | - |
dc.subject.MESH | Amniotic Fluid/metabolism* | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | C-Reactive Protein/analysis | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cytokines/analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Natural Childbirth/methods* | - |
dc.subject.MESH | Plasminogen Activator Inhibitor 1/analysis | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Pregnancy Trimester, Second/metabolism* | - |
dc.subject.MESH | Premature Birth/metabolism* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Twins/genetics | - |
dc.title | Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology | - |
dc.contributor.googleauthor | S M Lee | - |
dc.contributor.googleauthor | J S Park | - |
dc.contributor.googleauthor | E R Norwitz | - |
dc.contributor.googleauthor | S Oh | - |
dc.contributor.googleauthor | E J Kim | - |
dc.contributor.googleauthor | S M Kim | - |
dc.contributor.googleauthor | J Lee | - |
dc.contributor.googleauthor | B J Kim | - |
dc.contributor.googleauthor | C-W Park | - |
dc.contributor.googleauthor | J K Jun | - |
dc.identifier.doi | 10.1038/jp.2015.29 | - |
dc.contributor.localId | A04846 | - |
dc.relation.journalcode | J02889 | - |
dc.identifier.eissn | 1757-9996 | - |
dc.identifier.pmid | 25856763 | - |
dc.identifier.url | http://www.nature.com/jp/journal/v35/n8/full/jp201529a.html | - |
dc.contributor.alternativeName | Lee, Joon Ho | - |
dc.contributor.affiliatedAuthor | Lee, Joon Ho | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 542 | - |
dc.citation.endPage | 546 | - |
dc.identifier.bibliographicCitation | ORAL HEALTH & PREVENTIVE DENTISTRY, Vol.35(8) : 542-546, 2015 | - |
dc.identifier.rimsid | 48131 | - |
dc.type.rims | ART | - |
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