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Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study

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dc.contributor.author이준호-
dc.date.accessioned2018-01-23T05:49:02Z-
dc.date.available2018-01-23T05:49:02Z-
dc.date.issued2015-
dc.identifier.issn1602-1622-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155668-
dc.description.abstractOBJECTIVE: To evaluate the association between the concentrations of immune-related proteins in mid-trimester amniotic fluid (AF) and the subsequent risk of spontaneous preterm delivery in twins. STUDY DESIGN: The study population consisted of consecutive women with a twin pregnancy who underwent clinically indicated genetic amniocentesis at 15 to 20 weeks, and had a subsequent spontaneous delivery in the early preterm period (<32 weeks (cases)) or at term (37 to 42 weeks (controls)). AF was analyzed for cytokines (interleukin (IL)-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13 and IL-15, interferon-γ, tumor necrosis factor-α), matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-12), and chemokines (complement factor-D/Adipsin, Serpin E1/PAI-1, Adiponectin/Acrp30, C-Reactive Protein, CCL2/MCP-1, Leptin, Resistin) using multiplex immunoassay kits. The association between AF protein levels and subsequent early preterm birth were examined. RESULT: A total of 96 sets of twins were enrolled, including 17 early preterm birth cases and 79 term controls. AF concentrations of IL-6, IL-8, MMP-3, MMP-8 and MMP-9, and CCL2/MCP-1 were significantly higher in cases than controls. Among these analytes, the combination of AF IL-8 and MMP-9 values had the highest predictive value for early preterm birth. The risk was 8% (10/132) for IL-8<1200 pg ml(-1) and MMP-9<1000 pg ml(-1), 30% (15/50) for IL-8>1200 pg ml(-1) or MMP-9>1000 pg ml(-1), and 90% (9/10) for IL-8>1200 pg ml(-1) and MMP-9>1000 pg ml(-1) (P<0.001). CONCLUSION: High concentrations of IL-8 and MMP-9 in mid-trimester AF in twins predicted well the risk of early preterm birth.-
dc.description.statementOfResponsibilityrestriction-
dc.relation.isPartOfORAL HEALTH & PREVENTIVE DENTISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAmniocentesis/methods-
dc.subject.MESHAmniotic Fluid/metabolism*-
dc.subject.MESHBiomarkers/analysis-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCytokines/analysis*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHNatural Childbirth/methods*-
dc.subject.MESHPlasminogen Activator Inhibitor 1/analysis-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy Trimester, Second/metabolism*-
dc.subject.MESHPremature Birth/metabolism*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTwins/genetics-
dc.titleMid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorS M Lee-
dc.contributor.googleauthorJ S Park-
dc.contributor.googleauthorE R Norwitz-
dc.contributor.googleauthorS Oh-
dc.contributor.googleauthorE J Kim-
dc.contributor.googleauthorS M Kim-
dc.contributor.googleauthorJ Lee-
dc.contributor.googleauthorB J Kim-
dc.contributor.googleauthorC-W Park-
dc.contributor.googleauthorJ K Jun-
dc.identifier.doi10.1038/jp.2015.29-
dc.contributor.localIdA04846-
dc.relation.journalcodeJ02889-
dc.identifier.eissn1757-9996-
dc.identifier.pmid25856763-
dc.identifier.urlhttp://www.nature.com/jp/journal/v35/n8/full/jp201529a.html-
dc.contributor.alternativeNameLee, Joon Ho-
dc.contributor.affiliatedAuthorLee, Joon Ho-
dc.citation.volume35-
dc.citation.number8-
dc.citation.startPage542-
dc.citation.endPage546-
dc.identifier.bibliographicCitationORAL HEALTH & PREVENTIVE DENTISTRY, Vol.35(8) : 542-546, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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