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Prognostic Significance of Defining L-Cell Type on the Biologic Behavior of Rectal Neuroendocrine Tumors in Relation with Pathological Parameters
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.date.accessioned | 2018-01-23T05:48:48Z | - |
dc.date.available | 2018-01-23T05:48:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/155658 | - |
dc.description.abstract | PURPOSE: In 2010, the World Health Organization categorized L-cell type neuroendocrine tumors (NETs) as tumors of uncertain malignancy, while all others were classified as malignant. However, the diagnostic necessity of L-cell immunophenotyping is unclear, as are tumor stage and grade that may guide diagnosis and management. To clarify the predictive markers of rectal neuroendocrine neoplasms (NENs), 5- and 10-year overall survival (OS) was analyzed by pathological parameters including L-cell phenotype. MATERIALS AND METHODS: A total of 2,385 rectal NENs were analyzed from our previous multicenter study and a subset of 170 rectal NENs was immunophenotyped. RESULTS: In univariate survival analysis, tumor grade (p < 0.0001), extent (p < 0.0001), size (p < 0.0001), lymph node metastasis (p=0.0063), and L-cell phenotype (p < 0.0001) showed significant correlation with the prognosis of rectal NENs; however, none of these markers achieved independent significance in multivariate analysis. The 10-year OS of tumors of NET grade 1, < 10 mm, the mucosa/submucosa was 97.58%, 99.47%, and 99.03%, respectively. L-Cell marker, glucagon II (GLP-1&2), with a cut off score of > 10, is useful in defining L-Cell type. In this study, an L-cell immunophenotype was found in 83.5% of all rectal NENs and most, but not all L-cell type tumors were NET G1, small (< 10 mm) and confined to the mucosa/submucosa. CONCLUSION: From these results, the biological behavior of rectal NENs does not appear to be determined by L-cell type alone but instead by a combination of pathological parameters. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Immunophenotyping/methods* | - |
dc.subject.MESH | Lymph Nodes/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neuroendocrine Tumors/classification | - |
dc.subject.MESH | Neuroendocrine Tumors/pathology* | - |
dc.subject.MESH | Rectal Neoplasms/classification | - |
dc.subject.MESH | Rectal Neoplasms/pathology* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Prognostic Significance of Defining L-Cell Type on the Biologic Behavior of Rectal Neuroendocrine Tumors in Relation with Pathological Parameters | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | - |
dc.contributor.googleauthor | Jin Hee Sohn | - |
dc.contributor.googleauthor | Mee-Yon Cho | - |
dc.contributor.googleauthor | Yangsoon Park | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Woo Ho Kim | - |
dc.contributor.googleauthor | Joon Mee Kim | - |
dc.contributor.googleauthor | Eun Sun Jung | - |
dc.contributor.googleauthor | Kyoung-Mee Kim | - |
dc.contributor.googleauthor | Jae Hyuk Lee | - |
dc.contributor.googleauthor | Hee Kyung Chan | - |
dc.contributor.googleauthor | Do Youn Park | - |
dc.contributor.googleauthor | Mee Joo | - |
dc.contributor.googleauthor | Sujin Kim | - |
dc.contributor.googleauthor | Woo Sung Moon | - |
dc.contributor.googleauthor | Mi Seon Kang | - |
dc.contributor.googleauthor | So-Young Jin | - |
dc.contributor.googleauthor | Yun Kyung Kang | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | HyeSeung Han | - |
dc.contributor.googleauthor | EunHee Choi | - |
dc.identifier.doi | 10.4143/crt.2014.238 | - |
dc.contributor.localId | A01108 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 25715764 | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | International Classification of Diseases | - |
dc.subject.keyword | L cells | - |
dc.subject.keyword | Neuroendocrine tumors | - |
dc.subject.keyword | Rectal neoplasms | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.citation.volume | 47 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 813 | - |
dc.citation.endPage | 822 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.47(4) : 813-822, 2015 | - |
dc.identifier.rimsid | 48122 | - |
dc.type.rims | ART | - |
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