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Is familial papillary thyroid microcarcinoma more aggressive than sporadic form?

DC FieldValueLanguage
dc.contributor.author강상욱-
dc.contributor.author박정수-
dc.contributor.author이잔디-
dc.contributor.author이초록-
dc.contributor.author정웅윤-
dc.contributor.author정종주-
dc.contributor.author남기현-
dc.date.accessioned2017-11-02T08:39:16Z-
dc.date.available2017-11-02T08:39:16Z-
dc.date.issued2017-
dc.identifier.issn2288-6575-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154723-
dc.description.abstractPURPOSE: With the increasing incidence of papillary thyroid microcarcinoma (PTMC), familial papillary thyroid microcarcinoma (FPTMC) is now recognized more frequently. However, the biological behavior of FPTMC is poorly understood. The aim of this study was to investigate the prevalence of FPTMC and its biological aggressiveness. METHODS: Between March 2006 and July 2010, 2,414 patients underwent primary surgical therapy for PTMC and 149 (6.2%) were further classified as FPTMC. To determine the biological aggressiveness of FPTMC, we compared the clinicopathological features and prognosis between FPTMC and sporadic PTMC (SPTMC). RESULTS: The male-to-female ratio was higher in FPTMC than in sporadic papillary thyroid microcarcinoma (SPTMC: 1:4.5 vs. 1:7.2, P = 0.041). The central lymph node (LN) metastasis rate was significantly higher in FPTMC than in SPTMC (36.2% vs. 24.2%, P = 0.002). The local recurrence rate was also higher in FPTMC than in SPTMC (4.5% vs. 0.6%, P < 0.001). We identified familial occurrence in 6.2% of cases of PTMC. FPTMC is associated with a high rate of central LN metastasis and local recurrence. CONCLUSION: These findings suggest that close follow-up can be beneficial in FPTMC patients to detect local recurrence.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Surgical Society-
dc.relation.isPartOfAnnals of Surgical Treatment and Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIs familial papillary thyroid microcarcinoma more aggressive than sporadic form?-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorCho Rok Lee-
dc.contributor.googleauthorSeulkee Park-
dc.contributor.googleauthorSang-Wook Kang-
dc.contributor.googleauthorJandee Lee-
dc.contributor.googleauthorJong Ju Jeong-
dc.contributor.googleauthorKee-Hyun Nam-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorCheong Soo Park-
dc.identifier.doi10.4174/astr.2017.92.3.129-
dc.contributor.localIdA01646-
dc.contributor.localIdA03066-
dc.contributor.localIdA03256-
dc.contributor.localIdA03674-
dc.contributor.localIdA03722-
dc.contributor.localIdA01245-
dc.contributor.localIdA00032-
dc.relation.journalcodeJ00180-
dc.relation.journalsince2014~-
dc.identifier.pmid28289666-
dc.relation.journalbefore~2013 Journal of the Korean Surgical Society-
dc.subject.keywordAggression-
dc.subject.keywordFamily-
dc.subject.keywordPapillary thyroid microcarcinoma-
dc.subject.keywordPrevalence-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameKang, Sang Wook-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameLee, Jan Dee-
dc.contributor.alternativeNameLee, Cho Rok-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameJeong, Jong Ju-
dc.contributor.alternativeNameNam, Kee Hyun-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.contributor.affiliatedAuthorLee, Jan Dee-
dc.contributor.affiliatedAuthorLee, Cho Rok-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.contributor.affiliatedAuthorJeong, Jong Ju-
dc.contributor.affiliatedAuthorNam, Kee Hyun-
dc.contributor.affiliatedAuthorKang, Sang Wook-
dc.citation.titleAnnals of Surgical Treatment and Research-
dc.citation.volume92-
dc.citation.number3-
dc.citation.startPage129-
dc.citation.endPage135-
dc.identifier.bibliographicCitationAnnals of Surgical Treatment and Research, Vol.92(3) : 129-135, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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