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In vitro fertilization outcome in women with diminished ovarian reserve

DC FieldValueLanguage
dc.contributor.author김기은-
dc.contributor.author최영식-
dc.contributor.author박선희-
dc.contributor.author서석교-
dc.contributor.author윤보현-
dc.contributor.author이병석-
dc.contributor.author조시현-
dc.date.accessioned2017-11-02T08:38:09Z-
dc.date.available2017-11-02T08:38:09Z-
dc.date.issued2017-
dc.identifier.issn2287-8572-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154699-
dc.description.abstractOBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases. RESULTS: The clinical pregnancy rate was 11.5% per cycle, and the total cancellation rate was 34.4%. Clinical pregnancy rate was significantly associated with the antral follicle count and the cause of the DOR. Age, serum anti-Müllerian hormone and follicle-stimulating hormone levels, antral follicle count, peak estradiol level, and the cause of DOR were significantly associated with cycle cancellation. However, history of previous ovarian surgery remained as a significant factor of clinical pregnancy (model 1: odds ratio [OR] 10.17, 95% confidence interval [CI] 1.46 to 70.84, P=0.019; model 2: OR 10.85, 95% CI 1.05 to 111.71, P=0.045). In cancellation models, idiopathic or previous chemotherapy group showed borderline significance (model 1: OR 3.76, 95% CI 0.83 to 17.04, P=0.086; model 2: OR 3.15, 95% CI 0.84 to 11.84, P=0.09). CONCLUSION: DOR caused by previous ovarian surgery may show better pregnancy outcome, whereas that caused by chemotherapy could significantly increase the cycle cancellation rate. Furthermore, patients with DOR who previously received gonadotoxic agents may show reduced efficacy and increased risk of IVF cycle cancellation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Obstetrics and Gynecology-
dc.relation.isPartOfObstetrics & Gynecology Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIn vitro fertilization outcome in women with diminished ovarian reserve-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorBo Hyon Yun-
dc.contributor.googleauthorGieun Kim-
dc.contributor.googleauthorSeon Hee Park-
dc.contributor.googleauthorEun Bee Noe-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi10.5468/ogs.2017.60.1.46-
dc.contributor.localIdA04114-
dc.contributor.localIdA05126-
dc.contributor.localIdA01888-
dc.contributor.localIdA02555-
dc.contributor.localIdA02795-
dc.contributor.localIdA03846-
dc.contributor.localIdA05090-
dc.relation.journalcodeJ02408-
dc.relation.journalsince2013~-
dc.identifier.pmid28217671-
dc.relation.journalbefore~2012 Korean Journal of Obstetrics and Gynecology-
dc.subject.keywordDiminished ovarian reserve-
dc.subject.keywordFertilization in vitro-
dc.contributor.alternativeNameKim, Gi Eun-
dc.contributor.alternativeNameChoi, Young Sik-
dc.contributor.alternativeNamePark, Seon Hee-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameYun, Bo Hyon-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.affiliatedAuthorChoi, Young Sik-
dc.contributor.affiliatedAuthorPark, Seon Hee-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorYun, Bo Hyon-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.contributor.affiliatedAuthorKim, Gi Eun-
dc.citation.titleObstetrics & Gynecology Science-
dc.citation.volume60-
dc.citation.number1-
dc.citation.startPage46-
dc.citation.endPage52-
dc.identifier.bibliographicCitationObstetrics & Gynecology Science, Vol.60(1) : 46-52, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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