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5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells

Authors
 HanGoo Kang  ;  Seungjae Kim  ;  Kwang Hoon Lee  ;  Shan Jin  ;  Seo Hyeong Kim  ;  Kangtaek Lee  ;  Hyungjoon Jeon  ;  Young-Geon Song  ;  Sang-Won Lee  ;  Jinwon Seo  ;  Soomin Park  ;  In-Hong Choi 
Citation
 SMALL, Vol.13(9) : 1602363, 2017 
Journal Title
 SMALL 
ISSN
 1613-6810 
Issue Date
2017
Keywords
allergic reactions ; atopic dermatitis ; mast cells ; reactive oxygen species ; silver nanoparticles
Abstract
The triggering effect of silver nanoparticles (NPs) on the induction of allergic reactions is evaluated, by studying the activation of mast cells and the clinical features of atopic dermatitis in a mouse model. Granule release is induced in RBL-2H3 mast cells by 5 nm, but not 100 nm silver NPs. Increases in the levels of reactive oxygen species (hydrogen peroxide and mitochondrial superoxide) and intracellular Ca++ in mast cells are induced by 5 nm silver NPs. In a mouse model of atopic dermatitis induced by a mite allergen, the skin lesions are more severe and appear earlier in mice treated simultaneously with 5 nm silver NPs and allergen compared with mice treated with allergen alone or 100 nm silver NPs and allergen. The histological findings reveal that number of tryptase-positive mast cells and total IgE levels in the serum increase in mice treated with 5 nm silver NPs and allergen. The results in this study indicate that cotreatment with 5 nm silver NPs stimulates mast cell degranulation and induces earlier and more severe clinical alterations in allergy-prone individuals.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.201602363/abstract
DOI
10.1002/smll.201602363
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154698
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