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Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김은정-
dc.contributor.author김정민-
dc.contributor.author이재훈-
dc.date.accessioned2017-11-02T08:36:09Z-
dc.date.available2017-11-02T08:36:09Z-
dc.date.issued2017-
dc.identifier.issn1976-9148-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154662-
dc.description.abstractThe interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley rats, focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 1 h. The rats simultaneously received 50 mg/kg human IL-1RA through the intranasal (IN group) or intraperitoneal route (IP group). The other rats were given 0.5 mL/kg normal saline (EC group). Neurobehavioral function, infarct size, and the concentration of the administered human IL-1RA in the brain tissue were assessed. In addition, the cellular distribution of intranasal IL-1RA in the brain and its effect on proinflammatory cytokines expression were evaluated. Intranasal IL-1RA improved neurological deficit and reduced infarct size until 7 days after MCAO (p<0.05). The concentrations of the human IL-1RA in the brain tissue 24 h after MCAO were significantly greater in the IN group than in the IP group (p<0.05). The human IL-1RA was confirmed to be co-localized with neuron and microglia. Furthermore, the IN group had lower expression of interleukin-1β and tumor necrosis factor-α at 6 h after MCAO than the EC group (p<0.05). These results suggest that intranasal IL-1RA can reach the brain parenchyma more efficiently and provide superior neuroprotection in the transient focal cerebral ischemia.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorean Society of Applied Pharmacology-
dc.relation.isPartOfBIOMOLECULES & THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIntranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorEun Hee Kam-
dc.contributor.googleauthorJeong Min Kim-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorEun Jeong Kim-
dc.contributor.googleauthorSo Yeong Cheon-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.identifier.doi10.4062/biomolther.2016.050-
dc.contributor.localIdA00616-
dc.contributor.localIdA00816-
dc.contributor.localIdA00884-
dc.contributor.localIdA03092-
dc.contributor.localIdA00193-
dc.relation.journalcodeJ00324-
dc.identifier.eissn2005-4483-
dc.relation.journalsince2008~-
dc.identifier.pmid27530114-
dc.relation.journalbefore~2007 Journal of Applied Pharmacology-
dc.subject.keywordCerebral ischemia-
dc.subject.keywordInterleukin-1 receptor antagonist-
dc.subject.keywordIntranasal administration-
dc.subject.keywordNeuroinflammation-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Eun Jung-
dc.contributor.alternativeNameKim, Jeongmin-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorKim, Eun Jung-
dc.contributor.affiliatedAuthorKim, Jeongmin-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.citation.titleBiomolecules & Therapeutics-
dc.citation.volume25-
dc.citation.number2-
dc.citation.startPage149-
dc.citation.endPage157-
dc.identifier.bibliographicCitationBIOMOLECULES & THERAPEUTICS, Vol.25(2) : 149-157, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43722-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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