Cited 17 times in
Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김은정 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 이재훈 | - |
dc.date.accessioned | 2017-11-02T08:36:09Z | - |
dc.date.available | 2017-11-02T08:36:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154662 | - |
dc.description.abstract | The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley rats, focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 1 h. The rats simultaneously received 50 mg/kg human IL-1RA through the intranasal (IN group) or intraperitoneal route (IP group). The other rats were given 0.5 mL/kg normal saline (EC group). Neurobehavioral function, infarct size, and the concentration of the administered human IL-1RA in the brain tissue were assessed. In addition, the cellular distribution of intranasal IL-1RA in the brain and its effect on proinflammatory cytokines expression were evaluated. Intranasal IL-1RA improved neurological deficit and reduced infarct size until 7 days after MCAO (p<0.05). The concentrations of the human IL-1RA in the brain tissue 24 h after MCAO were significantly greater in the IN group than in the IP group (p<0.05). The human IL-1RA was confirmed to be co-localized with neuron and microglia. Furthermore, the IN group had lower expression of interleukin-1β and tumor necrosis factor-α at 6 h after MCAO than the EC group (p<0.05). These results suggest that intranasal IL-1RA can reach the brain parenchyma more efficiently and provide superior neuroprotection in the transient focal cerebral ischemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Applied Pharmacology | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Eun Hee Kam | - |
dc.contributor.googleauthor | Jeong Min Kim | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Eun Jeong Kim | - |
dc.contributor.googleauthor | So Yeong Cheon | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.4062/biomolther.2016.050 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A00816 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A03092 | - |
dc.contributor.localId | A00193 | - |
dc.relation.journalcode | J00324 | - |
dc.identifier.eissn | 2005-4483 | - |
dc.relation.journalsince | 2008~ | - |
dc.identifier.pmid | 27530114 | - |
dc.relation.journalbefore | ~2007 Journal of Applied Pharmacology | - |
dc.subject.keyword | Cerebral ischemia | - |
dc.subject.keyword | Interleukin-1 receptor antagonist | - |
dc.subject.keyword | Intranasal administration | - |
dc.subject.keyword | Neuroinflammation | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Kim, Jeongmin | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jeongmin | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 157 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, Vol.25(2) : 149-157, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43722 | - |
dc.type.rims | ART | - |
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