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Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics

DC Field Value Language
dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author양필성-
dc.contributor.author엄재선-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.date.accessioned2017-11-02T08:35:47Z-
dc.date.available2017-11-02T08:35:47Z-
dc.date.issued2017-
dc.identifier.issn0914-5087-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154655-
dc.description.abstractBACKGROUND: Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF. METHODS: Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8±9.7 years) who were followed >12 months after RFCA. RESULTS: During 25 (19-35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p=0.010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR=2.70, 95% CI 1.41-5.14, p=0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12-65 months (log rank, p=0.025). CONCLUSIONS: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months.-
dc.description.statementOfResponsibilityrestriction-
dc.languageJapanese, English-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAtrial Fibrillation/genetics*-
dc.subject.MESHAtrial Fibrillation/pathology-
dc.subject.MESHAtrial Fibrillation/surgery*-
dc.subject.MESHCatheter Ablation*/adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHeart Atria/pathology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHRecurrence-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleGood responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJin-Kyu Park-
dc.contributor.googleauthorJi-Young Lee-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorEunsoon Shin-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1016/j.jjcc.2016.04.017-
dc.contributor.localIdA01776-
dc.contributor.localIdA02323-
dc.contributor.localIdA02337-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA01085-
dc.relation.journalcodeJ01287-
dc.identifier.eissn1876-4738-
dc.identifier.pmid27261248-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0914508716300788-
dc.subject.keywordAblation-
dc.subject.keywordGenetic polymorphism-
dc.subject.keywordLong-standing persistent atrial fibrillation-
dc.contributor.alternativeNameKim, Tae Hoon-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameYang, Pil Sung-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorYang, Pil Sung-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorKim, Tae-Hoon-
dc.citation.titleJournal of Cardiology-
dc.citation.volume69-
dc.citation.number3-
dc.citation.startPage584-
dc.citation.endPage590-
dc.identifier.bibliographicCitationJOURNAL OF CARDIOLOGY, Vol.69(3) : 584-590, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43714-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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