Cited 15 times in
Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 양필성 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2017-11-02T08:35:47Z | - |
dc.date.available | 2017-11-02T08:35:47Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0914-5087 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154655 | - |
dc.description.abstract | BACKGROUND: Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF. METHODS: Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8±9.7 years) who were followed >12 months after RFCA. RESULTS: During 25 (19-35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p=0.010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR=2.70, 95% CI 1.41-5.14, p=0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12-65 months (log rank, p=0.025). CONCLUSIONS: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Japanese, English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Atrial Fibrillation/genetics* | - |
dc.subject.MESH | Atrial Fibrillation/pathology | - |
dc.subject.MESH | Atrial Fibrillation/surgery* | - |
dc.subject.MESH | Catheter Ablation*/adverse effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Heart Atria/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Postoperative Complications | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jin-Kyu Park | - |
dc.contributor.googleauthor | Ji-Young Lee | - |
dc.contributor.googleauthor | Pil-Sung Yang | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Eunsoon Shin | - |
dc.contributor.googleauthor | Junbeom Park | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1016/j.jjcc.2016.04.017 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02323 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A01085 | - |
dc.relation.journalcode | J01287 | - |
dc.identifier.eissn | 1876-4738 | - |
dc.identifier.pmid | 27261248 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0914508716300788 | - |
dc.subject.keyword | Ablation | - |
dc.subject.keyword | Genetic polymorphism | - |
dc.subject.keyword | Long-standing persistent atrial fibrillation | - |
dc.contributor.alternativeName | Kim, Tae Hoon | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Yang, Pil Sung | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Yang, Pil Sung | - |
dc.contributor.affiliatedAuthor | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hoon | - |
dc.citation.title | Journal of Cardiology | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 584 | - |
dc.citation.endPage | 590 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOLOGY, Vol.69(3) : 584-590, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43714 | - |
dc.type.rims | ART | - |
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