Cited 59 times in
Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2017-11-02T08:35:26Z | - |
dc.date.available | 2017-11-02T08:35:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154648 | - |
dc.description.abstract | BACKGROUND: Non-obstructive coronary artery disease (CAD) identified by coronary computed tomography angiography (CCTA) demonstrated prognostic value. CT-adapted Leaman score (CT-LeSc) showed to improve the prognostic stratification. Aim of the study was to evaluate the capability of CT-LeSc to assess long-term prognosis of patients with non-obstructive (CAD). METHODS: From 17 centers, we enrolled 2402 patients without prior CAD history who underwent CCTA that showed non-obstructive CAD and provided complete information on plaque composition. Patients were divided into a group without CAD and a group with non-obstructive CAD (<50% stenosis). Segment-involvement score (SIS) and CT-LeSc were calculated. Outcomes were non-fatal myocardial infarction (MI) and the combined end-point of MI and all-cause mortality. RESULTS: Patient mean age was 56±12years. At follow-up (mean 59.8±13.9months), 183 events occurred (53 MI, 99 all-cause deaths and 31 late revascularizations). CT-LeSc was the only multivariate predictor of MI (HRs 2.84 and 2.98 in two models with Framingham and risk factors, respectively) and of MI plus all-cause mortality (HR 2.48 and 1.94 in two models with Framingham and risk factors, respectively). This was confirmed by a net reclassification analysis confirming that the CT-LeSc was able to correctly reclassify a significant proportion of patients (cNRI 0.28 and 0.23 for MI and MI plus all-cause mortality, respectively) vs. baseline model, whereas SIS did not. CONCLUSION: CT-LeSc is an independent predictor of major acute cardiac events, improving prognostic stratification of patients with non-obstructive CAD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cause of Death/trends | - |
dc.subject.MESH | Computed Tomography Angiography/methods* | - |
dc.subject.MESH | Coronary Angiography/methods* | - |
dc.subject.MESH | Coronary Artery Disease/diagnosis* | - |
dc.subject.MESH | Coronary Artery Disease/mortality | - |
dc.subject.MESH | Coronary Vessels/diagnostic imaging* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Global Health | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Registries* | - |
dc.subject.MESH | Risk Assessment/methods* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.title | Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Saima Mushtaq | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Edoardo Conte | - |
dc.contributor.googleauthor | Antonio L. Bartorelli | - |
dc.contributor.googleauthor | Mauro Pepi | - |
dc.contributor.googleauthor | Maksymilian P. Opolski | - |
dc.contributor.googleauthor | Bríain ó Hartaigh | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz Al-Mallah | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J.W. Chow | - |
dc.contributor.googleauthor | Ricardo Cury | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Philipp A. Kaufmann | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Gilbert Raff | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.contributor.googleauthor | Hugo Marques | - |
dc.contributor.googleauthor | Ronen Rubinshtein | - |
dc.contributor.googleauthor | Niree Hindoyan | - |
dc.contributor.googleauthor | Millie Gomez | - |
dc.contributor.googleauthor | James K Min | - |
dc.identifier.doi | 10.1016/j.ijcard.2016.12.137 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 28082093 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167527316321167 | - |
dc.subject.keyword | CT-adapted Leaman score | - |
dc.subject.keyword | Coronary CT angiography | - |
dc.subject.keyword | Non-obstructive CAD | - |
dc.subject.keyword | Patients reclassification | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.citation.title | International Journal of Cardiology | - |
dc.citation.volume | 231 | - |
dc.citation.startPage | 18 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.231 : 18-25, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43705 | - |
dc.type.rims | ART | - |
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