Cited 2 times in
Treatment of uncomplicated hypertension is associated with a reduction in cardiovascular mortality: a Korean national cohort study
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.date.accessioned | 2017-11-02T08:34:12Z | - |
dc.date.available | 2017-11-02T08:34:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154623 | - |
dc.description.abstract | BACKGROUND: Although the benefit of hypertension treatment is well established in high-risk patients, there is a paucity of evidence regarding the benefit of treatment in patients with uncomplicated hypertension. METHODS: Hypertensive adult patients were selected from the Korea National Health Insurance Sample Cohort in 2002 and were followed until 2013. Patients with a diagnosis of heart failure, coronary artery disease, stroke, malignancy, diabetes, or chronic kidney disease were excluded. Ultimately, 40 496 patients were divided into three groups: never-treated (N = 6756), treated-from-baseline (N = 28 443), and treated-during-follow-up (N = 5297). Five first-line antihypertensive agents were categorized into four classes: renin-angiotensin system blocker (RASB), beta-blocker, calcium channel blocker (CCB), and diuretics. All-cause mortality, cardiovascular mortality, and hazard ratio were determined. RESULTS: All-cause and cardiovascular mortality rates were significantly lower in both treatment groups than in the never-treated group (all log-rank P < 0.001). Treatment from baseline (hazard ratio = 0.49 for all-cause mortality and hazard ratio = 0.62 for cardiovascular mortality) and treatment started during follow-up (hazard ratio = 0.41 for all-cause mortality and hazard ratio = 0.44 for cardiovascular mortality) were independently associated with lower mortality on multivariable Cox analyses. Although RASB, beta-blocker, and CCB significantly reduced all-cause mortality, multivariable Cox analyses showed that RASB and CCB were closely associated with lower all-cause mortality. In terms of cardiovascular mortality, only CCB was associated with lower cardiovascular mortality on multivariable Cox analyses. CONCLUSION: Treatment of hypertension significantly reduces mortality in patients with uncomplicated hypertension. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic beta-Antagonists/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Angiotensin Receptor Antagonists/therapeutic use | - |
dc.subject.MESH | Angiotensin-Converting Enzyme Inhibitors/therapeutic use | - |
dc.subject.MESH | Antihypertensive Agents/therapeutic use* | - |
dc.subject.MESH | Calcium Channel Blockers/therapeutic use | - |
dc.subject.MESH | Cause of Death* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diuretics/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/drug therapy* | - |
dc.subject.MESH | Hypertension/mortality* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Treatment of uncomplicated hypertension is associated with a reduction in cardiovascular mortality: a Korean national cohort study | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Lee, Chan J | - |
dc.contributor.googleauthor | Hwang, Jinseub | - |
dc.contributor.googleauthor | Oh, Jaewon | - |
dc.contributor.googleauthor | Lee, Sang-Hak | - |
dc.contributor.googleauthor | Kang, Seok-Min | - |
dc.contributor.googleauthor | Choi, Donghoon | - |
dc.contributor.googleauthor | Kim, Hyeon-Chang | - |
dc.contributor.googleauthor | Park, Sungha | - |
dc.identifier.doi | 10.1097/HJH.0000000000001331 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J01448 | - |
dc.identifier.eissn | 1473-5598 | - |
dc.identifier.pmid | 28350620 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004872-201705001-00007&D=ovft&PDF=y | - |
dc.subject.keyword | antihypertensive agents | - |
dc.subject.keyword | cohort | - |
dc.subject.keyword | hypertension treatment | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | uncomplicated hypertension | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.citation.title | Journal of Hypertension | - |
dc.citation.volume | 35 | - |
dc.citation.number | Suppl. 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 49 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, Vol.35(Suppl. 1) : 41-49, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43680 | - |
dc.type.rims | ART | - |
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