Cited 13 times in
Feasibility and Efficacy of Intra-Arterial Administration of Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy.
DC Field | Value | Language |
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dc.contributor.author | 이필휴 | - |
dc.date.accessioned | 2017-11-02T08:33:59Z | - |
dc.date.available | 2017-11-02T08:33:59Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2157-6564 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154616 | - |
dc.description.abstract | Multiple system atrophy (MSA) is a sporadic neurodegenerative disease of the central and autonomic nervous system. Because no drug treatment consistently benefits MSA patients, neuroprotective strategy using mesenchymal stem cells (MSCs) has a lot of concern for the management of MSA. In this study, we investigated the safety and efficacy of intra-arterial administration of MSCs via internal carotid artery (ICA) in an animal model of MSA. The study was composed of feasibility test using a ×10 and ×50 of a standard dose of MSCs (4 × 107 MSCs) and efficacy test using a ×0.2, ×2, and ×20 of the standard dose. An ultrasonic flow meter and magnetic resonance imaging (MRI) showed that no cerebral ischemic lesions with patent ICA blood flow was were observed in animals receiving a ×10 of the standard dose of MSCs. However, no MSA animals receiving a ×50 of the standard dose survived. In efficacy test, animals injected with a ×2 of the standard dose increased nigrostriatal neuronal survival relative to a ×0.2 or ×20 of the standard dose. MSA animals receiving MSCs at ×0.2 and ×2 concentrations of the standard dose exhibited a significant reduction in rotation behavior relative to ×20 of the standard dose of MSCs. Cerebral ischemic lesions on MRI were only observed in MSA animals receiving a ×20 of the standard dose. The present study revealed that if their concentration is appropriate, intra-arterial injection of MSCs is safe and exerts a neuroprotective effect on striatal and nigral neurons with a coincidental improvement in motor behavior. Stem Cells Translational Medicine 2017;6:1424-1433. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | AlphaMed Press. | - |
dc.relation.isPartOf | STEM CELLS TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Feasibility and Efficacy of Intra-Arterial Administration of Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Ha Na Kim | - |
dc.contributor.googleauthor | Dong Yeol Kim | - |
dc.contributor.googleauthor | Se Hee Oh | - |
dc.contributor.googleauthor | Hyung Sook Kim | - |
dc.contributor.googleauthor | Kyung Suk Kim | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1002/sctm.16-0438 | - |
dc.contributor.localId | A03270 | - |
dc.relation.journalcode | J02686 | - |
dc.identifier.eissn | 2157-6580 | - |
dc.identifier.pmid | 28296268 | - |
dc.subject.keyword | Efficacy | - |
dc.subject.keyword | Feasibility | - |
dc.subject.keyword | Intra-arterial injection | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Multiple system atrophy | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.citation.title | Stem Cells Translational Medicine | - |
dc.citation.volume | 6 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1424 | - |
dc.citation.endPage | 1433 | - |
dc.identifier.bibliographicCitation | STEM CELLS TRANSLATIONAL MEDICINE, Vol.6(5) : 1424-1433, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43672 | - |
dc.type.rims | ART | - |
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