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Extremely Well-Differentiated Papillary Thyroid Carcinoma Resembling Adenomatous Hyperplasia Can Metastasize to the Skull: A Case Report

DC FieldValueLanguage
dc.contributor.author김석모-
dc.contributor.author김지섭-
dc.contributor.author박정수-
dc.contributor.author홍순원-
dc.contributor.author최성은-
dc.date.accessioned2017-11-02T08:33:35Z-
dc.date.available2017-11-02T08:33:35Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154607-
dc.description.abstractWe describe herein histologic, immunohistochemical, and molecular findings and clinical manifestations of a rare case of an extremely well differentiated papillary thyroid carcinoma (EWD-PTC). Similarly, it is also difficult to diagnose follicular variant papillary thyroid carcinoma (FVPTC), whose diagnosis is still met with controversy. A recently reported entity of well-differentiated tumor of uncertain malignant potential (WDT-UMP) is added to the diagnostic spectrum harboring EWD-PTC and FVPTC. We report this case, because EWD-PTC is different from FVPTC in its papillary architecture, and also from WDT-UMP in its recurrence and metastatic pattern. These morphologically deceptive entities harbored diagnostic difficulties in the past because the diagnosis depended solely on histology. However, they are now diagnosed with more certainty by virtue of immunohistochemical and molecular studies. We experienced a case of EWD-PTC, which had been diagnosed as adenomatous hyperplasia 20 years ago and manifested recurrence with lymph node (LN) metastasis 7 years later. After another 7 years of follow-up, a new thyroid lesion had developed, diagnosed as FVPTC, with LN metastasis of EWD-PTC. One year later, the patient developed metastatic FVPTC in the skull. Immunohistochemically, the EWD-PTC was focally positive for CK19, negative for galectin-3, and focally negative for CD56. Molecular studies revealed BRAF-positivity and K-RAS negativity. The FVPTC in the left thyroid showed both BRAF and K-RAS negativity. In conclusion, EWD-PTC and FVPTC share similar histologic features, but they are different tumors with different molecular biologic and clinical manifestations. A large cohort of EWD-PTC should be included in further study.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma, Follicular/pathology-
dc.subject.MESHAdenocarcinoma, Follicular/secondary-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoma, Papillary, Follicular/pathology-
dc.subject.MESHCarcinoma, Papillary, Follicular/secondary*-
dc.subject.MESHFemale-
dc.subject.MESHGalectin 3/analysis-
dc.subject.MESHHumans-
dc.subject.MESHHyperplasia/pathology-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHSkull Neoplasms/secondary*-
dc.subject.MESHThyroid Neoplasms/pathology*-
dc.titleExtremely Well-Differentiated Papillary Thyroid Carcinoma Resembling Adenomatous Hyperplasia Can Metastasize to the Skull: A Case Report-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJu Yeon Pyo-
dc.contributor.googleauthorJisup Kim-
dc.contributor.googleauthorSung-eun Choi-
dc.contributor.googleauthorEunah Shin-
dc.contributor.googleauthorSeok-Woo Yang-
dc.contributor.googleauthorCheong Soo Park-
dc.contributor.googleauthorSeok-Mo Kim-
dc.contributor.googleauthorSoonWon Hong-
dc.identifier.doi10.3349/ymj.2017.58.1.255-
dc.contributor.localIdA04912-
dc.contributor.localIdA01646-
dc.contributor.localIdA04411-
dc.contributor.localIdA00542-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid27873522-
dc.subject.keywordCD56, immunohistochemistry-
dc.subject.keywordadenomatous hyperplasia-
dc.subject.keywordextremely well-differentiated-
dc.subject.keywordfollicular epithelial dysplasia-
dc.subject.keywordpapillary thyroid carcinoma-
dc.subject.keywordwell-differentiated tumors of uncertain malignant potential-
dc.contributor.alternativeNameKim, Seok Mo-
dc.contributor.alternativeNameKim, Ji Seop-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Jisup-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Seok Mo-
dc.citation.titleYonsei Medical Journal-
dc.citation.volume58-
dc.citation.number1-
dc.citation.startPage255-
dc.citation.endPage258-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(1) : 255-258, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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