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Efficacy of aspirin and statins in primary prevention of cardiovascular mortality in uncomplicated hypertensive participants: a Korean national cohort study

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author이상학-
dc.contributor.author최동훈-
dc.date.accessioned2017-11-02T08:31:38Z-
dc.date.available2017-11-02T08:31:38Z-
dc.date.issued2017-
dc.identifier.issn0263-6352-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154566-
dc.description.abstractINTRODUCTION: To determine whether the addition of aspirin to a statin regimen is beneficial in reducing cardiovascular mortality, we analyzed data for uncomplicated hypertensive patients included in the Korea National Health Insurance sample cohort. METHOD: Among the 758 433 eligible participants aged 20 years or older in 2005, 31 115 participants were selected and divided into four groups: no-treatment group (N = 19 628); aspirin alone group (N = 4814); statins alone group (N = 4717); and combined treatment group (N = 1956). The mean follow-up duration was 94 ± 13 months. The primary outcome of the study was all-cause and cardiovascular mortality from 2007 to 2013. RESULTS: Treatment with aspirin alone [hazard ratio (HR), 0.62; 95% confidence interval (CI), 0.55-0.70; P < 0.001), treatment with statins alone (HR, 0.48; 95% CI, 0.41-0.57; P < 0.001), and combined treatment (HR, 0.43; 95% CI, 0.34-0.55; P < 0.001) were independently associated with reductions in all-cause mortality. Treatment with aspirin alone (HR, 0.66; 95% CI, 0.53-0.84; P < 0.001), treatment with statins alone (HR, 0.46; 95% CI, 0.33-0.64; P < 0.001), and combined treatment (HR, 0.50; 95% CI, 0.31-0.79; P = 0.003) were also independently associated with reductions in cardiovascular mortality. The addition of aspirin to statins was not associated with an additive benefit in reducing total mortality or cardiovascular mortality. CONCLUSION: : Primary prevention with aspirin and/or statins is beneficial in reducing both all-cause and cardiovascular mortality in uncomplicated hypertensive participants. Nevertheless, as aspirin administration is associated with an increased risk of major bleeding, care must be taken to assess the risk/benefit of using aspirin in primary prevention.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJournal of Hypertension-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/therapeutic use*-
dc.subject.MESHAspirin/therapeutic use*-
dc.subject.MESHCause of Death-
dc.subject.MESHCohort Studies-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*-
dc.subject.MESHHypertension/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Ischemia/mortality-
dc.subject.MESHMyocardial Ischemia/prevention & control*-
dc.subject.MESHPrimary Prevention-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHStroke/mortality-
dc.subject.MESHStroke/prevention & control*-
dc.subject.MESHYoung Adult-
dc.titleEfficacy of aspirin and statins in primary prevention of cardiovascular mortality in uncomplicated hypertensive participants: a Korean national cohort study-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorHyeon-Chang Kim-
dc.contributor.googleauthorSungha Park-
dc.identifier.doi10.1097/HJH.0000000000001279-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA02395-
dc.contributor.localIdA02833-
dc.contributor.localIdA04053-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ01448-
dc.identifier.pmid28129248-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004872-201705001-00006&D=ovft&PDF=y-
dc.subject.keywordaspirin-
dc.subject.keywordhypertension-
dc.subject.keywordprimary prevention-
dc.subject.keywordstatins-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.alternativeNameLee, Snag Hak-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.citation.titleJournal of Hypertension-
dc.citation.volume35-
dc.citation.numberSuppl. 1-
dc.citation.startPage33-
dc.citation.endPage40-
dc.identifier.bibliographicCitationJournal of Hypertension, Vol.35(Suppl. 1) : 33-40, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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