Cited 32 times in
Evaluation of Spleen Glucose Metabolism Using 18F-FDG PET/CT in Patients with Febrile Autoimmune Disease
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.contributor.author | 황상현 | - |
dc.date.accessioned | 2017-11-02T08:31:03Z | - |
dc.date.available | 2017-11-02T08:31:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154557 | - |
dc.description.abstract | The purpose of this study was to evaluate the clinical significance of 18F-FDG uptake by the spleen in patients with autoimmune disease. Methods: We retrospectively reviewed Severance Hospital's electronic medical records of patients hospitalized for the evaluation of fever who underwent 18F-FDG PET/CT. We found 91 patients with autoimmune diseases and 101 patients with localized infection. 18F-FDG uptake was assessed by measuring SUV in the spleen and liver. The spleen-to-liver ratio of the SUVmean (SLRmean) was calculated. Clinical and laboratory parameters were collected and evaluated for association with SLRmean In-hospital mortality was defined as all-cause mortality during hospital admission for fever. Results: SLRmean was significantly higher in autoimmune disease than in localized infectious disease (1.28 ± 0.43 vs. 0.91 ± 0.21, P < 0.001). In autoimmune disease, SLRmean was correlated with monocytes, aspartate aminotransferase, alanine aminotransferase, albumin, and ferritin. Analysis of receiver-operating-characteristic curves revealed that in comparison with laboratory parameters, SLRmean had the highest performance in differentiating autoimmune from localized infectious disease. Multivariate logistic regression analysis demonstrated that high SLRmean and low platelets were significantly associated with in-hospital mortality in febrile autoimmune disease. Conclusion: These findings suggest that spleen glucose metabolism is increased in febrile autoimmune disease. Spleen 18F-FDG uptake may provide information useful in differentiating febrile autoimmune disease from localized infectious disease and predicting clinical outcomes in febrile autoimmune disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Society of Nuclear Medicine | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Autoimmune Diseases/complications | - |
dc.subject.MESH | Autoimmune Diseases/diagnostic imaging | - |
dc.subject.MESH | Autoimmune Diseases/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fever of Unknown Origin/diagnostic imaging | - |
dc.subject.MESH | Fever of Unknown Origin/etiology | - |
dc.subject.MESH | Fever of Unknown Origin/metabolism* | - |
dc.subject.MESH | Fluorodeoxyglucose F18/pharmacokinetics | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Clearance Rate | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Imaging/methods* | - |
dc.subject.MESH | Organ Specificity Positron Emission Tomography Computed Tomography/methods* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Spleen/diagnostic imaging | - |
dc.subject.MESH | Spleen/metabolism* | - |
dc.subject.MESH | Tissue Distribution | - |
dc.subject.MESH | Young Adult | - |
dc.title | Evaluation of Spleen Glucose Metabolism Using 18F-FDG PET/CT in Patients with Febrile Autoimmune Disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Sang Hyun Hwang | - |
dc.contributor.googleauthor | Seung Min Jung | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.identifier.doi | 10.2967/jnumed.116.180729 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.contributor.localId | A01579 | - |
dc.relation.journalcode | J01644 | - |
dc.identifier.eissn | 1535-5667 | - |
dc.identifier.pmid | 27688472 | - |
dc.identifier.url | http://jnm.snmjournals.org/content/58/3/507.long | - |
dc.subject.keyword | 18F-FDG PET/CT | - |
dc.subject.keyword | autoimmune disease | - |
dc.subject.keyword | bone marrow | - |
dc.subject.keyword | immunometabolism | - |
dc.subject.keyword | spleen | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.citation.title | Journal of Nuclear Medicine | - |
dc.citation.volume | 58 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 507 | - |
dc.citation.endPage | 513 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, Vol.58(3) : 507-513, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43607 | - |
dc.type.rims | ART | - |
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