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Mucinous Carcinoma with Extensive Signet Ring Cell Differentiation: A Case Report

Authors
 Hye Min Kim  ;  Eun Kyung Kim  ;  Ja Seung Koo 
Citation
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.51(2) : 176-179, 2017 
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
ISSN
 2383-7837 
Issue Date
2017
Keywords
Breast ; Mucinous carcinoma ; Signet ring cell
Abstract
Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin. In a case with signet ring cell differentiation, differential diagnosis with metastatic signet ring cell carcinoma of the stomach and colon is essential. In this case, the presence of accompanied ductal carcinoma in situ component and mammaglobin and gross cystic disease fluid protein-15 positivity were findings that suggested the breast as the origin.
Files in This Item:
T201700680.pdf Download
DOI
10.4132/jptm.2016.08.17
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Eun Kyung(김은경)
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154524
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