Cited 21 times in
Short-versus long-term Dual Antiplatelet therapy after drug-eluting stent implantation in women versus men: A sex-specific patient-level pooled-analysis of six randomized trials
DC Field | Value | Language |
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dc.contributor.author | 김병극 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2017-11-02T08:27:30Z | - |
dc.date.available | 2017-11-02T08:27:30Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1522-1946 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154489 | - |
dc.description.abstract | BACKGROUND: Whether the efficacy and safety of dual antiplatelet therapy (DAPT) are uniform between sexes is unclear. We sought to compare clinical outcomes between short- (≤6 months) versus long-term (≥1 year) DAPT after drug-eluting stent (DES) placement in women and men. METHODS AND RESULTS: We pooled individual patient data from 6 randomized trials of DAPT (EXCELLENT, OPTIMIZE, PRODIGY, RESET, SECURITY, ITALIC PLUS). The primary outcome was 1-year risk of major adverse cardiac events (MACE). The main secondary outcome was 1-year risk of any bleeding. Out of the 11,473 randomized patients included in the pooled dataset, 3,454 (30%) were females. At 1-year follow-up, women had higher risk of MACE (3.6% vs. 2.8%; P = 0.01) but similar risk of bleeding (1.9% vs. 1.6%; P = 0.16) as compared with men. Compared with long-term DAPT, short-term DAPT was associated with similar rates of MACE in both women (HR 0.88; 95% CI 0.62-1.25) and men (HR 1.25; 95% CI 0.95-1.6; P interaction = 0.08)]. At 1-year follow-up, short-term DAPT was associated with lower rates of bleeding as compared with long-term DAPT in both women (HR 0.84; 95% CI 0.51-1.37) and men (HR 0.58; 95% CI 0.40-0.84; P-interaction = 0.25). The presence of MVD was associated with higher MACE rates in the short-term DAPT group in women (HR: 1.16; CI 0.60-2.23) and men (HR: 2.29; CI 1.22-4.29; P interaction = 0.25). CONCLUSIONS: Short-term DAPT is associated with similar rates of MACE but lower risk of bleeding when as compared with prolonged DAPT. There was no significant difference between sexes in the population studied. © 2016 Wiley Periodicals, Inc. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Coronary Thrombosis/etiology | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemorrhage/chemically induced | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Myocardial Infarction/etiology | - |
dc.subject.MESH | Percutaneous Coronary Intervention/adverse effects | - |
dc.subject.MESH | Percutaneous Coronary Intervention/instrumentation* | - |
dc.subject.MESH | Percutaneous Coronary Intervention/mortality | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/administration & dosage* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/adverse effects | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Randomized Controlled Trials as Topic | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Short-versus long-term Dual Antiplatelet therapy after drug-eluting stent implantation in women versus men: A sex-specific patient-level pooled-analysis of six randomized trials | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Fadi J. Sawaya | - |
dc.contributor.googleauthor | Marie-Claude Morice | - |
dc.contributor.googleauthor | Marco Spaziano | - |
dc.contributor.googleauthor | Roxana Mehran | - |
dc.contributor.googleauthor | Romain Didier | - |
dc.contributor.googleauthor | Andrew Roy | - |
dc.contributor.googleauthor | Marco Valgimigli | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Kyung Woo Park | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Fausto Feres | - |
dc.contributor.googleauthor | Alexandre Abizaid | - |
dc.contributor.googleauthor | Ricardo A. Costa | - |
dc.contributor.googleauthor | Antonio Colombo | - |
dc.contributor.googleauthor | Alaide Chieffo | - |
dc.contributor.googleauthor | Gennaro Giustino | - |
dc.contributor.googleauthor | Gregg W. Stone | - |
dc.contributor.googleauthor | Deepak L. Bhatt | - |
dc.contributor.googleauthor | Tullio Palmerini | - |
dc.contributor.googleauthor | Martine Gilard | - |
dc.identifier.doi | 10.1002/ccd.26653 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00493 | - |
dc.relation.journalcode | J00471 | - |
dc.identifier.eissn | 2451-9456 | - |
dc.identifier.pmid | 27426936 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ccd.26653/abstract | - |
dc.subject.keyword | drug-eluting stents | - |
dc.subject.keyword | dual antiplatelet therapy duration | - |
dc.subject.keyword | major adverse cardiac events | - |
dc.subject.keyword | women | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.citation.title | Catheterization and Cardiovascular Interventions | - |
dc.citation.volume | 89 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 189 | - |
dc.identifier.bibliographicCitation | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol.89(2) : 178-189, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43062 | - |
dc.type.rims | ART | - |
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