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Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Authors
 Aastha Kukreja  ;  Byunghoon Kang  ;  Hyun-Ouk Kim  ;  Eunji Jang  ;  Hye Young Son  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Journal of Industrial and Engineering Chemistry, Vol.48 : 56-65, 2017 
Journal Title
 Journal of Industrial and Engineering Chemistry 
ISSN
 1226-086X 
Issue Date
2017
Keywords
Dual imaging ; Iron oxide–gold nanoparticles ; MR imaging ; CT imaging
Abstract
Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.
Full Text
http://www.sciencedirect.com/science/article/pii/S1226086X16305196
DOI
10.1016/j.jiec.2016.12.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
손혜영(Son, Hye Yeong) ORCID logo https://orcid.org/0000-0001-5977-6784
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154477
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