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Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author권영은-
dc.contributor.author기연경-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author윤창연-
dc.contributor.author한승규-
dc.contributor.author한승혁-
dc.date.accessioned2017-11-02T08:26:14Z-
dc.date.available2017-11-02T08:26:14Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154467-
dc.description.abstractBACKGROUND: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). METHOD: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. RESULTS: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036). CONCLUSION: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.-
dc.description.statementOfResponsibilityopen-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Kidney Injury/blood-
dc.subject.MESHAcute Kidney Injury/mortality*-
dc.subject.MESHAcute Kidney Injury/pathology*-
dc.subject.MESHCausality-
dc.subject.MESHFemale-
dc.subject.MESHGranulocytes/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLeukocyte Count/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRenal Replacement Therapy/mortality*-
dc.subject.MESHRenal Replacement Therapy/utilization-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment/methods-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSepsis/blood-
dc.subject.MESHSepsis/mortality*-
dc.subject.MESHSepsis/pathology*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleDelta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorIn Mi Han-
dc.contributor.googleauthorChang-Yun Yoon-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorYoun Kyung Kee-
dc.contributor.googleauthorSeung Gyu Han-
dc.contributor.googleauthorYoung Eun Kwon-
dc.contributor.googleauthorKyoung Sook Park-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1186/s12882-017-0507-8-
dc.contributor.localIdA00232-
dc.contributor.localIdA00276-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA02613-
dc.contributor.localIdA04298-
dc.contributor.localIdA04304-
dc.contributor.localIdA00053-
dc.relation.journalcodeJ00367-
dc.identifier.eissn1471-2369-
dc.relation.journalsince2000~-
dc.identifier.pmid28320333-
dc.subject.keywordContinuous renal replacement therapy-
dc.subject.keywordDelta neutrophil index-
dc.subject.keywordMortality-
dc.subject.keywordSeptic acute kidney injury-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKwon, Young Eun-
dc.contributor.alternativeNameKee, Youn Kyung-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameYoon, Chang Yun-
dc.contributor.alternativeNameHan, Seung Gyu-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKwon, Young Eun-
dc.contributor.affiliatedAuthorKee, Youn Kyung-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorYoon, Chang Yun-
dc.contributor.affiliatedAuthorHan, Seung Gyu-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.citation.titleBMC Nephrology-
dc.citation.volume18-
dc.citation.number94-
dc.citation.startPage1-
dc.citation.endPage10-
dc.identifier.bibliographicCitationBMC NEPHROLOGY, Vol.18(94) : 1-10, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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