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Comparison of Dexmedetomidine and Fentanyl as an Adjuvant to Ropivacaine for Postoperative Epidural Analgesia in Pediatric Orthopedic Surgery

DC FieldValueLanguage
dc.contributor.author김승현-
dc.contributor.author김신형-
dc.contributor.author김현우-
dc.contributor.author도해윤-
dc.contributor.author박상준-
dc.contributor.author신서경-
dc.contributor.author최용선-
dc.date.accessioned2017-11-02T08:25:51Z-
dc.date.available2017-11-02T08:25:51Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154459-
dc.description.abstractPURPOSE: Opioids are commonly used as an epidural adjuvant to local anesthetics, but are associated with potentially serious side effects, such as respiratory depression. The aim of this study was to compare the efficacy and safety of dexmedetomidine with that of fentanyl as an adjuvant to epidural ropivacaine in pediatric orthopedic surgery. MATERIALS AND METHODS: This study enrolled 60 children (3-12 years old) scheduled for orthopedic surgery of the lower extremities and lumbar epidural patient-controlled analgesia (PCA). Children received either dexmedetomidine (1 μg/kg) or fentanyl (1 μg/kg) along with 0.2% ropivacaine (0.2 mL/kg) via an epidural catheter at 30 minutes before the end of surgery. Postoperatively, the children were observed for ropivacaine consumption via epidural PCA, postoperative pain intensity, need for rescue analgesics, emergence agitation, and other adverse effects. RESULTS: The mean dose of bolus epidural ropivacaine was significantly lower within the first 6 h after surgery in the dexmedetomidine group, compared with the fentanyl group (0.029±0.030 mg/kg/h vs. 0.053±0.039 mg/kg/h, p=0.012). The median pain score at postoperative 6 h was also lower in the dexmedetomidine group, compared to the fentanyl group [0 (0-1.0) vs. 1.0 (0-3.0), p=0.039]. However, there was no difference in the need for rescue analgesia throughout the study period between groups. CONCLUSION: The use of dexmedetomidine as an epidural adjuvant had a significantly greater analgesic and local anesthetic-sparing effect, compared to fentanyl, in the early postoperative period in children undergoing major orthopedic lower extremity surgery.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmides/administration & dosage*-
dc.subject.MESHAnalgesia, Epidural/methods*-
dc.subject.MESHAnalgesia, Patient-Controlled/methods*-
dc.subject.MESHAnalgesics/therapeutic use-
dc.subject.MESHAnalgesics, Opioid/administration & dosage-
dc.subject.MESHAnesthesia, Epidural-
dc.subject.MESHAnesthetics, Local/administration & dosage*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDexmedetomidine/administration & dosage*-
dc.subject.MESHDexmedetomidine/therapeutic use-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHFentanyl/administration & dosage*-
dc.subject.MESHFentanyl/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Epidural-
dc.subject.MESHLeg/surgery*-
dc.subject.MESHMale-
dc.subject.MESHOrthopedic Procedures*-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHPostoperative Period-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of Dexmedetomidine and Fentanyl as an Adjuvant to Ropivacaine for Postoperative Epidural Analgesia in Pediatric Orthopedic Surgery-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorSang Jun Park-
dc.contributor.googleauthorSeokyung Shin-
dc.contributor.googleauthorShin Hyung Kim-
dc.contributor.googleauthorHyun Woo Kim-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorHae Yoon Do-
dc.contributor.googleauthorYong Seon Choi-
dc.identifier.doi10.3349/ymj.2017.58.3.650-
dc.contributor.localIdA00676-
dc.contributor.localIdA01124-
dc.contributor.localIdA05122-
dc.contributor.localIdA04933-
dc.contributor.localIdA02109-
dc.contributor.localIdA04119-
dc.contributor.localIdA05098-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28332374-
dc.subject.keywordDexmedetomidine-
dc.subject.keywordepidural analgesia-
dc.subject.keywordfentanyl-
dc.contributor.alternativeNameKim, Seung Hyun-
dc.contributor.alternativeNameKim, Shin Hyung-
dc.contributor.alternativeNameKim, Hyun Woo-
dc.contributor.alternativeNameDo, Hae Yoon-
dc.contributor.alternativeNamePark, Sang Jun-
dc.contributor.alternativeNameShin, Seo Kyung-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.affiliatedAuthorKim, Shin Hyung-
dc.contributor.affiliatedAuthorKim, Hyun Woo-
dc.contributor.affiliatedAuthorDo, Hae Yoon-
dc.contributor.affiliatedAuthorPark, Sang Jun-
dc.contributor.affiliatedAuthorShin, Seo Kyung-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorKim, Seung Hyun-
dc.citation.titleYonsei Medical Journal-
dc.citation.volume58-
dc.citation.number3-
dc.citation.startPage650-
dc.citation.endPage657-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(3) : 650-657, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43035-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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