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Indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy

Authors
 Kwang Suk Lee  ;  Kyo Chul Koo  ;  Kang Su Cho  ;  Seung Hwan Lee  ;  Woong Kyu Han  ;  Young Deuk Choi  ;  Sung Joon Hong  ;  Sang Un Park  ;  Suk Young Lee  ;  Woo Jin Ko  ;  Young Sig Kim  ;  Byung Ha Chung 
Citation
 Prostate International, Vol.5(1) : 24-28, 2017 
Journal Title
 Prostate International 
ISSN
 2287-8882 
Issue Date
2017
Keywords
Biopsy cores ; Prostate biopsy ; Prostate-specific antigen
Abstract
BACKGROUND: The present study aimed to evaluate the indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy. METHODS: The present study included 421 patients who underwent repeat prostate biopsy between January 2007 and December 2015 at three hospitals. Clinicopathological data, including patient age, body mass index, history of prostate biopsy, prostate volume, prostate-specific antigen (PSA) level, PSA density, PSA velocity, and PSA fluctuation patterns, were analyzed. The patients were stratified into two groups based on the first PSA pattern (increase/decrease) within 1 year after the initial negative prostate biopsy. RESULTS: Prostate cancer was detected in 100 (23.8%) of the 421 patients at the second prostate biopsy. In patients with a PSA decrease at the first follow-up, prostate volume and number of increases in the PSA level from the initial prostate biopsy were predictors for prostate cancer diagnosis at the second prostate biopsy. In patients with a steady PSA increase after the initial prostate biopsy, prostate volume and number of biopsy cores were predictors for prostate cancer diagnosis at the second prostate biopsy. CONCLUSION: The indications for a second prostate biopsy are a low prostate volume and a high number of increases in the PSA level among patients with a PSA decrease at the first follow-up and a low prostate volume and a high number of biopsy cores among patients with a PSA increase at the first follow-up.
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DOI
10.1016/j.prnil.2016.12.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
구교철(Koo, Kyo Chul) ORCID logo https://orcid.org/0000-0001-7303-6256
이광석(Lee, Kwang Suk) ORCID logo https://orcid.org/0000-0002-7961-8393
이승환(Lee, Seung Hwan) ORCID logo https://orcid.org/0000-0001-7358-8544
정병하(Chung, Byung Ha) ORCID logo https://orcid.org/0000-0001-9817-3660
조강수(Cho, Kang Su) ORCID logo https://orcid.org/0000-0002-3500-8833
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
홍성준(Hong, Sung Joon) ORCID logo https://orcid.org/0000-0001-9869-065X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154454
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