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Clinical Pharmacokinetics of Caffeine in Korean Preterm Infants with Apnea of Prematurity

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dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author신정은-
dc.contributor.author은호선-
dc.contributor.author이순민-
dc.contributor.author임명섭-
dc.date.accessioned2017-11-02T08:25:14Z-
dc.date.available2017-11-02T08:25:14Z-
dc.date.issued2017-
dc.identifier.issn2287-9412-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154449-
dc.description.abstractPurpose : Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug monitoring (TDM) may be needed. The PK profile of caffeine in Korean preterm neonates was investigated, and factors influencing the clearance of caffeine were analyzed. Methods : Fifty-nine preterm neonates receiving caffeine for apnea of prematurity were enrolled in the study (gestational age, 29.5±2.2 weeks and birth weight [BW], 1,318±358 g). Caffeine (20 mg/kg) was intravenously administered to each neonate as a loading dose, followed by a maintenance dose of 5-10 mg/kg/d. A total of 190 serum concentrations were measured for population PK analysis and modeling using nonlinear mixed-effects model (NONMEM®) software. Results : The mean serum concentration of caffeine was 15.4±4.5 mg/L (range 7.8-33.0 mg/L). High serum concentrations (>20 mg/L) were noted in 36 samples (29%). At the first measurement of serum caffeine, the mean postmenstrual age was 33.9±2.3 weeks, mean BW was 1,802±471 g, mean duration of treatment was 7.4±9.4 days, and mean sampling time after the last dose was 21.8±2.1 hours. In the population PK analysis, the clearance was 0.033 L/h and volume of distribution was 0.371 L. Typical clearance was calculated as 0.0293×(BW/70)1.33. Among the subjects receiving 5 mg/kg/d caffeine, the most significant risk factor associated with high serum concentrations (>20 mg/L) was low BW (P=0.024). Conclusion : BW was the only covariate that influenced caffeine clearance in preterm neonates. Preterm neonates with low BW should be carefully monitored for apnea and adverse reactions in addition to undergoing TDM.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorean Society of Neonatology-
dc.relation.isPartOfNeonatal Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical Pharmacokinetics of Caffeine in Korean Preterm Infants with Apnea of Prematurity-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorMyung Seop Lim-
dc.contributor.googleauthorMi Jeong Son-
dc.contributor.googleauthorJung Eun Shin-
dc.contributor.googleauthorSoon Min Lee-
dc.contributor.googleauthorHo Sun Eun-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorKook In Park-
dc.contributor.googleauthorRan Namgung-
dc.identifier.doi10.5385/nm.2017.24.1.20-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA02152-
dc.contributor.localIdA02635-
dc.contributor.localIdA02905-
dc.contributor.localIdA05173-
dc.contributor.localIdA01241-
dc.relation.journalcodeJ02310-
dc.relation.journalsince2013~-
dc.relation.journalbefore~2012 Journal of the Korean Society of Neonatology (대한신생아학회지)-
dc.subject.keywordApnea of prematurity-
dc.subject.keywordCaffeine-
dc.subject.keywordClearance-
dc.subject.keywordPharmacokinetics-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameShin, Jeong Eun-
dc.contributor.alternativeNameEun, Ho Seon-
dc.contributor.alternativeNameLee, Soon Min-
dc.contributor.alternativeNameLim, Myung Seop-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorShin, Jeong Eun-
dc.contributor.affiliatedAuthorEun, Ho Seon-
dc.contributor.affiliatedAuthorLee, Soon Min-
dc.contributor.affiliatedAuthorLim, Myung Seop-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.citation.titleNeonatal Medicine-
dc.citation.volume24-
dc.citation.number1-
dc.citation.startPage20-
dc.citation.endPage25-
dc.identifier.bibliographicCitationNeonatal Medicine, Vol.24(1) : 20-25, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43025-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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