Cited 4 times in
Expression of DNA methylation-related proteins in metastatic breast cancer.
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2017-11-02T08:24:09Z | - |
dc.date.available | 2017-11-02T08:24:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0028-2685 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154426 | - |
dc.description.abstract | We aimed to investigate the expression of methylation-related proteins (5-meC and DNMT1) in the metastatic breast cancers of variable sites and its association with clinicopathologic factors. A total of 126 metastatic breast cancers (31 bone metastases, 36 brain metastases, 11 liver metastases, 48 lung metastases) were made into tissue microarray and immunohistochemical staining of ER, PR, HER-2, Ki-67, 5-meC, and DNMT1 were performed. Molecular classification was made on the basis of immunohistochemical staining result of ER, PR, HER-2, Ki-67; luminal A, luminal B, HER-2, triple negative breast cancer (TNBC). Methylation-related proteins were differentially expressed based on the metastatic sites. Tumoral and stromal 5-meC showed the lowest expression in the bone metastasis (P < 0.001), tumoral DNMT1 showed the least expression in bone metastasis and the highest expression in the brain metastasis (P < 0.001). Expression of DNMT1 was correlated with ER negativity (P = 0.004), PR negativity (P = 0.011), HER-2 positivity (P = 0.016), higher Ki-67 labeling indices (P = 0.016), and non-luminal A type (P = 0.017). DNMT1 positivity was associated with shorter overall survival in bone metastasis (P = 0.017) and lung metastasis (P = 0.028) by univariate analysis. In conclusion, methylation-related proteins differentially expressed according to the metastatic sites in metastatic breast cancer. Tumoral and stromal 5-meC showed the lowest expression in the bone metastasis. Tumoral DNMT1 expression was low in bone metastasis and highest in brain metastasis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | AE Press | - |
dc.relation.isPartOf | NEOPLASMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of DNA methylation-related proteins in metastatic breast cancer. | - |
dc.type | Article | - |
dc.publisher.location | Slovakia | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Y. J. Cha | - |
dc.contributor.googleauthor | W. H. JUNG | - |
dc.contributor.googleauthor | J. S. KOO | - |
dc.identifier.doi | 10.4149/neo_2017_312 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J02313 | - |
dc.identifier.eissn | 1338-4317 | - |
dc.identifier.pmid | 28253728 | - |
dc.identifier.url | http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=5131&category_id=133&option=com_virtuemart&vmcchk=1&Itemid=1 | - |
dc.subject.keyword | 5-meC metastasis | - |
dc.subject.keyword | DNA methylation | - |
dc.subject.keyword | DNMT1 | - |
dc.subject.keyword | breast cancer | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.title | Neoplasma | - |
dc.citation.volume | 64 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 412 | - |
dc.citation.endPage | 420 | - |
dc.identifier.bibliographicCitation | NEOPLASMA, Vol.64(3) : 412-420, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43001 | - |
dc.type.rims | ART | - |
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