Cited 12 times in
Isoflurane Postconditioning Inhibits tPA-Induced Matrix Metalloproteinases Activation After Hypoxic Injury via Low-Density Lipoprotein Receptor-Related Protein and Extracellular Signal-Regulated Kinase Pathway
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 박미란 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김은정 | - |
dc.contributor.author | 김정민 | - |
dc.date.accessioned | 2017-11-02T08:23:54Z | - |
dc.date.available | 2017-11-02T08:23:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154421 | - |
dc.description.abstract | Tissue plasminogen activator (tPA) is the only recommended pharmacological treatment for acute ischemic stroke. However, tPA can induce intracerebral hemorrhage by blood-brain barrier breakdown through an increase in matrix metalloproteinases (MMPs). Previously, we showed that isoflurane postconditioning reduced intracranial hemorrhage following tPA treatment after cerebral ischemia. Here, we investigated the mechanism by which isoflurane postconditioning reduces tPA-induced MMP-2 and MMP-9 activation following hypoxia/reoxygenation (H/R) in brain endothelial cells. Mouse brain endothelial cells (bEnd.3) were exposed to 6 h of oxygen-glucose deprivation and 3 h of reoxygenation with tPA. Cells were treated with isoflurane for 1 h of the reoxygenation condition and the effect of isoflurane postconditioning on MMP-2 and MMP-9 activation was assessed. Involvement of low-density lipoprotein receptor-related protein (LRP), which is a receptor for tPA, and the extracellular signal-regulated kinase (ERK) and NF-κB pathway in isoflurane postconditioning was assessed using LRP inhibitor (receptor-associated protein, RAP) and ERK-1/2 inhibitor (PD98059). Isoflurane postconditioning decreased tPA-induced MMP-2 and MMP-9 activation under H/R. tPA treatment under H/R increased expression of LRP and the active form of NF-κB. Isoflurane postconditioning suppressed LRP expression, increased ERK-1/2 activation, and suppressed MMP-2 and MMP-9 activation, comparable to the effect of RAP. Activation of ERK-1/2, inhibition of NF-κB activation, and suppression of MMP-2 and MMP-9 activation by isoflurane postconditioning were abolished with PD98059 treatment. These finding indicate that isoflurane postconditioning inhibits tPA-induced MMP-2 and MMP-9 activation following H/R via the LRP/ERK/NF-κB pathway in bEnd.3. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.relation.isPartOf | NEUROCHEMICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Inhalation/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Hypoxia/drug effects | - |
dc.subject.MESH | Cell Hypoxia/physiology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cell Survival/physiology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Endothelial Cells/drug effects | - |
dc.subject.MESH | Endothelial Cells/metabolism | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Enzyme Activation/physiology | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism* | - |
dc.subject.MESH | Ischemic Postconditioning/methods* | - |
dc.subject.MESH | Isoflurane/pharmacology* | - |
dc.subject.MESH | Low Density Lipoprotein Receptor-Related Protein-1/metabolism* | - |
dc.subject.MESH | Matrix Metalloproteinases/metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Tissue Plasminogen Activator/antagonists & inhibitors | - |
dc.subject.MESH | Tissue Plasminogen Activator/pharmacology* | - |
dc.title | Isoflurane Postconditioning Inhibits tPA-Induced Matrix Metalloproteinases Activation After Hypoxic Injury via Low-Density Lipoprotein Receptor-Related Protein and Extracellular Signal-Regulated Kinase Pathway | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | So Yeong Cheon | - |
dc.contributor.googleauthor | Eun Jung Kim | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Eun Hee Kam | - |
dc.contributor.googleauthor | Jeong Min Kim | - |
dc.contributor.googleauthor | Miran Park | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.1007/s11064-017-2211-2 | - |
dc.contributor.localId | A04931 | - |
dc.contributor.localId | A03092 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A00816 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A00193 | - |
dc.relation.journalcode | J02325 | - |
dc.identifier.eissn | 1573-6903 | - |
dc.identifier.pmid | 28303501 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs11064-017-2211-2 | - |
dc.subject.keyword | Extracellular signal-regulated kinase | - |
dc.subject.keyword | Hypoxia | - |
dc.subject.keyword | Isoflurane | - |
dc.subject.keyword | Low-density lipoprotein receptor-related protein | - |
dc.subject.keyword | Matrix metalloproteinase | - |
dc.subject.keyword | Tissue plasminogen activator | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Park, Miran | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Kim, Jeongmin | - |
dc.contributor.affiliatedAuthor | Park, Miran | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jeongmin | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.citation.title | Neurochemical Research | - |
dc.citation.volume | 42 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1533 | - |
dc.citation.endPage | 1542 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, Vol.42(5) : 1533-1542, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42996 | - |
dc.type.rims | ART | - |
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