Cited 17 times in
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | 김은영 | - |
dc.contributor.author | 장윤수 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2017-11-02T08:21:40Z | - |
dc.date.available | 2017-11-02T08:21:40Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154378 | - |
dc.description.abstract | Aminoacyl-tRNA synthetase-interacting multi-functional protein 2 (AIMP2) works as potent tumor suppressor, while its splicing variant lacking exon 2 (AIMP2-DX2) competes with AIMP2 for binding to target proteins and compromises its anti-tumor activity. Assuming that AIMP2 and its variant AIMP2-DX2 could be released out to human sera in pathological condition, we investigated the diagnostic and prognostic usefulness of autoantibodies against AIMP2 and AIMP2-DX2 by measuring their serum levels in 80 normal and lung cancer samples that were matched in age, gender and smoking status. The area under the curve of AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 autoantibody ratio was low (0.416, 0.579, and 0.357, respectively), suggesting limited diagnostic value. A total of 165 lung cancer patients were classified into low and high AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 based on the median expression of each parameter. The high AIMP2-DX2 group was older and had larger tumors (>3 cm) than the low AIMP2-DX2 group. The high AIMP2-DX2/AIMP2 group had higher CYFRA-21 levels and significantly shorter overall survival than the low AIMP2-DX2/AIMP2 group (18.6 vs. 48.9 months, P = 0.021, Log Rank Test). Taken together, autoantibodies against AIMP2-DX2 and AIMP2 are detectable in the human blood and the increased ratio of AIMP2-DX2/AIMP2 is related to poor clinical outcome of lung cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer | - |
dc.type | Article | - |
dc.publisher.location | Australia | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Arum Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Nam Hoon Kwon | - |
dc.contributor.googleauthor | Youngji Moon | - |
dc.contributor.googleauthor | Eun Joo Kang | - |
dc.contributor.googleauthor | Jun Sik Sung | - |
dc.contributor.googleauthor | Hyunbo Shim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Yoon Soo Chang | - |
dc.identifier.doi | 10.7150/jca.18450 | - |
dc.contributor.localId | A03456 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00811 | - |
dc.relation.journalcode | J01281 | - |
dc.identifier.eissn | 1837-9664 | - |
dc.identifier.pmid | 28638448 | - |
dc.subject.keyword | Aminoacyl t-RNA synthetase (ARS) | - |
dc.subject.keyword | Aminoacyl t-RNA synthetase-interacting multi-functional protein 2 (AIMP2) | - |
dc.subject.keyword | Aminoacyl t-RNA synthetase-interacting multi-functional protein 2-exon 2 deletion (AIMP2-DX2) | - |
dc.subject.keyword | Autoantibody | - |
dc.subject.keyword | Lung cancer. | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Chang, Yoon Soo | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Chang, Yoon Soo | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.citation.title | Journal of Cancer | - |
dc.citation.volume | 8 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1347 | - |
dc.citation.endPage | 1354 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER, Vol.8(8) : 1347-1354, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42949 | - |
dc.type.rims | ART | - |
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