Cited 9 times in
β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성헌 | - |
dc.contributor.author | 정진세 | - |
dc.contributor.author | 최재영 | - |
dc.contributor.author | 문인석 | - |
dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2017-11-02T08:20:26Z | - |
dc.date.available | 2017-11-02T08:20:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154353 | - |
dc.description.abstract | The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere’s disease. Herein, we found, for the first time, functional evidence for the involvement of β1- and β2-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K+ and Cl− ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere’s disease. These results suggested that adrenergic stimulation via β1- and β2-adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere’s disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | Bo Gyung Kim | - |
dc.contributor.googleauthor | Jin Young Kim | - |
dc.contributor.googleauthor | JinSei Jung | - |
dc.contributor.googleauthor | In Seok Moon | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jae Young Choi | - |
dc.contributor.googleauthor | Sung Huhn Kim | - |
dc.identifier.doi | 10.1038/srep42217 | - |
dc.contributor.localId | A03742 | - |
dc.contributor.localId | A04173 | - |
dc.contributor.localId | A01374 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A00589 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 28165045 | - |
dc.contributor.alternativeName | Kim, Sung Huhn | - |
dc.contributor.alternativeName | Jung, Jinsei | - |
dc.contributor.alternativeName | Choi, Jae Young | - |
dc.contributor.alternativeName | Moon, In Seok | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Jung, Jinsei | - |
dc.contributor.affiliatedAuthor | Choi, Jae Young | - |
dc.contributor.affiliatedAuthor | Moon, In Seok | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Kim, Sung Huhn | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 42217 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.7 : 42217, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42923 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.