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β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications.

DC FieldValueLanguage
dc.contributor.author김성헌-
dc.contributor.author정진세-
dc.contributor.author최재영-
dc.contributor.author문인석-
dc.contributor.author윤주헌-
dc.date.accessioned2017-11-02T08:20:26Z-
dc.date.available2017-11-02T08:20:26Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154353-
dc.description.abstractThe endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere’s disease. Herein, we found, for the first time, functional evidence for the involvement of β1- and β2-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K+ and Cl− ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere’s disease. These results suggested that adrenergic stimulation via β1- and β2-adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere’s disease.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleβ1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorBo Gyung Kim-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorJinSei Jung-
dc.contributor.googleauthorIn Seok Moon-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorJae Young Choi-
dc.contributor.googleauthorSung Huhn Kim-
dc.identifier.doi10.1038/srep42217-
dc.contributor.localIdA03742-
dc.contributor.localIdA04173-
dc.contributor.localIdA01374-
dc.contributor.localIdA02604-
dc.contributor.localIdA00589-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28165045-
dc.contributor.alternativeNameKim, Sung Huhn-
dc.contributor.alternativeNameJung, Jinsei-
dc.contributor.alternativeNameChoi, Jae Young-
dc.contributor.alternativeNameMoon, In Seok-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.affiliatedAuthorJung, Jinsei-
dc.contributor.affiliatedAuthorChoi, Jae Young-
dc.contributor.affiliatedAuthorMoon, In Seok-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorKim, Sung Huhn-
dc.citation.titleScientific Reports-
dc.citation.volume7-
dc.citation.startPage42217-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.7 : 42217, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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