Cited 15 times in
Clinical outcomes of dual antiplatelet therapy after implantation of drug-eluting stents in patients with different cardiovascular risk factors
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 신동호 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2017-11-02T08:19:26Z | - |
dc.date.available | 2017-11-02T08:19:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1861-0684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154334 | - |
dc.description.abstract | BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation has not been established yet. The objectives of this study were to evaluate the optimal duration of DAPT after the DES implantation. METHODS: From three randomized controlled trials investigating DAPT duration after coronary stent implantation, we evaluated the clinical outcomes of short-term (6 months or less) DAPT compared with prolonged DAPT (12 months or more) in 1661 DES-treated pairs matched by propensity scores. At follow-up of 1 year, net adverse clinical event (NACE) was defined as cardiac death, myocardial infarction, target vessel revascularization, definite/probable stent thrombosis, or thrombolysis in myocardial infarction major bleeding. RESULTS: Short-term DAPT as compared with prolonged DAPT was not associated with 1-year NACEs after DES implantation [hazard ratio (HR) 1.068, 95 % confidence interval (CI) 0.787-1.450, p = 0.671]. Predictors for NACEs were old age (>75 years), hypertension, diabetes mellitus, renal dysfunction (serum creatinine ≥2.0 mg/dL), and multi-vessel disease. The DAPT strategy differentially contributed to the occurrence of NACEs according to the risk burden (p for interaction <0.001). In patients with low risk for NACEs, bleeding events were less in short-term DAPT than in prolonged DAPT (HR 0.332, 95 % CI 0.130-0.849, p = 0.021) (p for interaction = 0.098). Meanwhile, short-term DAPT was associated with more ischemic events that included cardiac death, myocardial infarction, target vessel revascularization, or definite/probable stent thrombosis (HR 2.164, 95 % CI 1.340-3.494, p = 0.002) (p for interaction <0.001) in patients with high risk for NACEs. CONCLUSION: One-year clinical outcomes of DAPT after DES implantation depended on the burden of cardiovascular risk. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | CLINICAL RESEARCH IN CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aspirin/administration & dosage* | - |
dc.subject.MESH | Coronary Artery Disease/diagnosis | - |
dc.subject.MESH | Coronary Artery Disease/surgery* | - |
dc.subject.MESH | Death, Sudden, Cardiac/epidemiology | - |
dc.subject.MESH | Death, Sudden, Cardiac/prevention & control* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/epidemiology | - |
dc.subject.MESH | Myocardial Infarction/prevention & control* | - |
dc.subject.MESH | Percutaneous Coronary Intervention* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/administration & dosage | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sirolimus/analogs & derivatives | - |
dc.subject.MESH | Sirolimus/pharmacology | - |
dc.subject.MESH | Ticlopidine/administration & dosage | - |
dc.subject.MESH | Ticlopidine/analogs & derivatives* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Clinical outcomes of dual antiplatelet therapy after implantation of drug-eluting stents in patients with different cardiovascular risk factors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Seung-Yul Lee | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Dong-Ho Shin | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Marco Valgimigli | - |
dc.contributor.googleauthor | Tullio Palmerini | - |
dc.contributor.googleauthor | Gregg W. Stone | - |
dc.identifier.doi | 10.1007/s00392-016-1035-4 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00127 | - |
dc.relation.journalcode | J03070 | - |
dc.identifier.eissn | 1861-0692 | - |
dc.relation.journalsince | 1997 | - |
dc.identifier.pmid | 27631821 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00392-016-1035-4 | - |
dc.subject.keyword | Antiplatelet therapy | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Drug-eluting stent | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.citation.title | Clinical Research in Cardiology | - |
dc.citation.volume | 106 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 173 | - |
dc.identifier.bibliographicCitation | CLINICAL RESEARCH IN CARDIOLOGY, Vol.106(3) : 165-173, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42903 | - |
dc.type.rims | ART | - |
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