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Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
DC Field | Value | Language |
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dc.contributor.author | 박영창 | - |
dc.contributor.author | 양규현 | - |
dc.contributor.author | 강호 | - |
dc.date.accessioned | 2017-11-02T08:15:03Z | - |
dc.date.available | 2017-11-02T08:15:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2287-6375 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154252 | - |
dc.description.abstract | BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. RESULTS: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. CONCLUSIONS: We have reviewed eight patients who were previously diagnosed as Paget's disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Bone and Mineral Research | - |
dc.relation.isPartOf | Journal of Bone Metabolism | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Orthopedic Surgery | - |
dc.contributor.googleauthor | Ho Kang | - |
dc.contributor.googleauthor | Young-Chang Park | - |
dc.contributor.googleauthor | Kyu Hyun Yang | - |
dc.identifier.doi | 10.11005/jbm.2017.24.2.97 | - |
dc.contributor.localId | A02282 | - |
dc.contributor.localId | A05082 | - |
dc.contributor.localId | A04569 | - |
dc.relation.journalcode | J02875 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 28642853 | - |
dc.relation.journalbefore | ~2011 JBM : Journal of Bone Metabolism | - |
dc.subject.keyword | Osteitis deformans | - |
dc.subject.keyword | Paget's disease of bone | - |
dc.contributor.alternativeName | Park, Young Chang | - |
dc.contributor.alternativeName | Yang, Kyu Hyun | - |
dc.contributor.alternativeName | Kang, Ho | - |
dc.contributor.affiliatedAuthor | Yang, Kyu Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Ho | - |
dc.contributor.affiliatedAuthor | Park, Young Chang | - |
dc.citation.title | Journal of Bone Metabolism | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 97 | - |
dc.citation.endPage | 103 | - |
dc.identifier.bibliographicCitation | Journal of Bone Metabolism, Vol.24(2) : 97-103, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42221 | - |
dc.type.rims | ART | - |
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