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Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock

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dc.contributor.author김세규-
dc.contributor.author김영삼-
dc.contributor.author박무석-
dc.contributor.author송주한-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.date.accessioned2017-11-02T08:14:27Z-
dc.date.available2017-11-02T08:14:27Z-
dc.date.issued2017-
dc.identifier.issn2383-4870-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154240-
dc.description.abstractBackground : The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone concentration (PAC) measurements compared with conventional severity indicators are associated with mortality in patients with septic shock. Methods : We evaluated 105 patients who were admitted for septic shock. Plasma levels of the biomarkers PRA and PAC, the PAC/PRA ratio, C-reactive protein (CRP) level, and cortisol level on days 1, 3, and 7 were serially measured. During the intensive care unit stay, relevant clinical information and laboratory results were recorded. Results : Patients were divided into two groups according to 28-day mortality: survivors (n = 59) and non-survivors (n = 46). The survivor group showed lower PRA, PAC, Acute Physiologic and Chronic Health Evaluation (APACHE) II score, and Sequential Organ Failure Assessment (SOFA) score than did the non-survivor group (all P < 0.05). The SOFA score was positively correlated with PRA (r = 0.373, P < 0.001) and PAC (r = 0.316, P = 0.001). According to receiver operating characteristic analysis, the areas under the curve of PRA and PAC to predict 28-day mortality were 0.69 (95% confidence interval [CI], 0.58 to 0.79; P = 0.001) and 0.67 (95% CI, 0.56 to 0.77; P = 0.003), respectively, similar to the APACHE II scores and SOFA scores. In particular, the group with PRA value ≥3.5 ng ml-1 h-1 on day 1 showed significantly greater mortality than did the group with PRA value <3.5 ng ml-1 h-1 (log-rank test, P < 0.001). According to multivariate analysis, SOFA score (hazard ratio, 1.11; 95% CI, 1.01 to 1.22), PRA value ≥3.5 ng ml-1 h-1 (hazard ratio, 3.25; 95% CI, 1.60 to 6.60), previous history of cancer (hazard ratio, 3.44; 95% CI, 1.72 to 6.90), and coronary arterial occlusive disease (hazard ratio, 2.99; 95% CI, 1.26 to 7.08) were predictors of 28-day mortality. Conclusions : Elevated PRA is a useful biomarker to stratify the risk of critically ill patients with septic shock and is a prognostic predictor of 28-day mortality.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Critical Care Medicine-
dc.relation.isPartOfKorean Journal of Critical Care Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImplications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorJoo Han Song-
dc.contributor.googleauthorWon Jai Jung-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorMoo Suk Park-
dc.identifier.doi10.4266/kjccm.2017.00094-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA02062-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA00602-
dc.relation.journalcodeJ01995-
dc.relation.journalsince2004~-
dc.relation.journalbefore~2003 Korean Journal of Critical Care Medicine (대한중환자의학회지)-
dc.subject.keywordaldosterone-
dc.subject.keywordmortality-
dc.subject.keywordrenin-
dc.subject.keywordshock, septic-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameSong, Joo Han-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorSong, Joo Han-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.citation.titleKorean Journal of Critical Care Medicine-
dc.citation.volume32-
dc.citation.number2-
dc.citation.startPage142-
dc.citation.endPage153-
dc.identifier.bibliographicCitationKorean Journal of Critical Care Medicine, Vol.32(2) : 142-153, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42209-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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