Cited 2 times in
Molecular Features of the V1-V4 Coding Region of Sexually Transmitted Human Immunodeficiency Virus Type 1
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2017-11-02T08:14:23Z | - |
dc.date.available | 2017-11-02T08:14:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154237 | - |
dc.description.abstract | BACKGROUND: Investigations into which human immunodeficiency virus type 1 (HIV-1) sequence features may be selected for transmission during sexual exposure have been hampered by the small number of characterized transmission pairs in individual studies. METHODS: To boost statistical power to detect differences in glycosylation, length, and electrical charge in the HIV-1 V1-V4 coding region, we reanalyzed all available 2485 env sequences derived from 114 subjects representing 58 transmission pairs from previous studies using mixed-effects linear regression and an approach to approximate the unobserved transmitted virus. RESULTS : The recipient partner had a shorter V1-V4 region and fewer potential N-linked glycosylation sites (PNGS) than sequences from the source partner. We also detected a trend toward more PNGS and lower isoelectric points in transmitted sequences with source partner and the evolutionary tendency to shorten V1-V4 sequences, reduce the number of PNGS, and lower isoelectric points in the recipient following transmission. CONCLUSIONS: By using all available well-characterized env sequences from transmission pairs via sexual exposure, we were able to identify several important virologic factors that may be important in the development of biomedical preventive interventions | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Evolution, Molecular | - |
dc.subject.MESH | Glycosylation | - |
dc.subject.MESH | HIV Envelope Protein gp120/chemistry | - |
dc.subject.MESH | HIV Envelope Protein gp120/genetics* | - |
dc.subject.MESH | HIV Envelope Protein gp120/metabolism | - |
dc.subject.MESH | HIV Infections/transmission* | - |
dc.subject.MESH | HIV Infections/virology* | - |
dc.subject.MESH | HIV-1/genetics* | - |
dc.subject.MESH | HIV-1/metabolism | - |
dc.subject.MESH | HIV-1/pathogenicity | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Peptide Fragments/genetics* | - |
dc.title | Molecular Features of the V1-V4 Coding Region of Sexually Transmitted Human Immunodeficiency Virus Type 1 | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Sergei L. Kosakovsky Pond | - |
dc.contributor.googleauthor | Christy M. Anderson | - |
dc.contributor.googleauthor | Douglas D. Richman | - |
dc.contributor.googleauthor | Davey M. Smith | - |
dc.identifier.doi | 10.1093/infdis/jix184 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01454 | - |
dc.identifier.eissn | 1537-6613 | - |
dc.identifier.pmid | 28419276 | - |
dc.identifier.url | https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jix184 | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | env | - |
dc.subject.keyword | transmitted virus | - |
dc.subject.keyword | viral evolution | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.citation.title | Journal of Infectious Diseases | - |
dc.citation.volume | 215 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1506 | - |
dc.citation.endPage | 1513 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, Vol.215(10) : 1506-1513, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42206 | - |
dc.type.rims | ART | - |
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