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RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

Authors
 Yong Cheol Shin  ;  Jeonghyo Kim  ;  Sung Eun Kim  ;  Su-Jin Song  ;  Suck Won Hong  ;  Jin-Woo Oh  ;  Jaebeom Lee  ;  Jong-Chul Park  ;  Suong-Hyu Hyon  ;  Dong-Wook Han 
Citation
 Regenerative Biomaterials, Vol.4(3) : 159-166, 2017 
Journal Title
 Regenerative Biomaterials 
ISSN
 2056-3418 
Issue Date
2017
Keywords
RGD peptide ; biofunctional scaffold ; graphene oxide ; poly(lactic-co-glycolic acid) ; vascular smooth muscle cell
Abstract
In recent years, much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular behaviors. In our study, RGD peptide and graphene oxide (GO) co-functionalized poly(lactide-co-glycolide, PLGA) (RGD-GO-PLGA) nanofiber mats were fabricated via electrospinning, and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue engineering. Scanning electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of random-oriented electrospun nanofibers with average diameter of 558 nm. The successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic analysis. Moreover, the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and GO. It was found that the mats were thermally stable under the cell culture condition. Furthermore, the initial attachment and proliferation of primarily cultured vascular smooth muscle cells (VSMCs) on the RGD-GO-PLGA nanofiber mats were evaluated. It was revealed that the RGD-GO-PLGA nanofiber mats can effectively promote the growth of VSMCs. In conclusion, our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.
Full Text
https://academic.oup.com/rb/article/4/3/159/2972206/RGD-peptide-and-graphene-oxide-co-functionalized
DOI
10.1093/rb/rbx001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154224
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