Cited 38 times in
Long-Term Recurrence of Small Papillary Thyroid Cancer and Its Risk Factors in a Korean Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 조영석 | - |
dc.date.accessioned | 2017-11-02T08:13:42Z | - |
dc.date.available | 2017-11-02T08:13:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154223 | - |
dc.description.abstract | CONTEXT: Small papillary thyroid cancer (PTC) generally has an excellent prognosis. However, long-term recurrence is not uncommon and sometimes leads to morbidity or mortality. OBJECTIVE: To identify high-risk factors for long-term recurrence in patients with small PTC by stratifying their pathologic characteristics. DESIGN, SETTING, AND PATIENTS: We conducted a nationwide, retrospective, multicenter study of 3282 patients with PTC sized ≤2 cm from 9 high-volume hospitals in Korea. MAIN OUTCOME MEASURES: The maximally selected χ2 method was used to find the best cutoff points of tumor size, the number of metastatic lymph nodes (LNs), and the ratio of metastatic/examined LNs (LNR) to predict recurrence. Kaplan-Meier analysis and the Cox proportional hazards regression model were used to analyze recurrence and risk factors. RESULTS: The optimal tumor size cutoff was 1.8 cm (10-year recurrence rates for tumors sized 0.1 to 1.7 cm and 1.8 to 2.0 cm: 7.7% vs 17.2%, respectively). Metastatic LNs ≤1 and ≥2 provided optimal estimates of recurrence (10-year recurrence rates: 4.0% vs 16.8%, respectively). The LNR of 0.19 was the optimal cutoff point for predicting the risk of recurrence (10-year recurrence rates for LNRs of 0 to 0.18 and 0.19 to 1: 2.7% vs 16.2%, respectively). LN metastasis, lobectomy, tumor size ≥1.8 cm, and bilateral tumors were independent risk factors for recurrence. CONCLUSIONS: Long-term recurrence was increased in patients who underwent lobectomy or with tumor sized ≥1.8 cm, 2 or more metastatic LNs, or bilateral tumors. For patients with these high-risk features, total thyroidectomy could be considered to avoid reoperation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Endocrine Society | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Carcinoma/diagnosis* | - |
dc.subject.MESH | Carcinoma/epidemiology | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma/surgery | - |
dc.subject.MESH | Carcinoma, Papillary | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/epidemiology | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment/methods* | - |
dc.subject.MESH | Risk Assessment/statistics & numerical data | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Thyroid Neoplasms/diagnosis* | - |
dc.subject.MESH | Thyroid Neoplasms/epidemiology | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.subject.MESH | Thyroid Neoplasms/surgery | - |
dc.subject.MESH | Thyroidectomy/methods* | - |
dc.subject.MESH | Thyroidectomy/statistics & numerical data | - |
dc.title | Long-Term Recurrence of Small Papillary Thyroid Cancer and Its Risk Factors in a Korean Multicenter Study | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Yul Hwangbo | - |
dc.contributor.googleauthor | Jung Min Kim | - |
dc.contributor.googleauthor | Young Joo Park | - |
dc.contributor.googleauthor | Eun Kyung Lee | - |
dc.contributor.googleauthor | You Jin Lee | - |
dc.contributor.googleauthor | Do Joon Park | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Kang Dae Lee | - |
dc.contributor.googleauthor | Seo Young Sohn | - |
dc.contributor.googleauthor | Sun Wook Kim | - |
dc.contributor.googleauthor | Jae Hoon Chung | - |
dc.contributor.googleauthor | Dong Jun Lim | - |
dc.contributor.googleauthor | Min Hee Kim | - |
dc.contributor.googleauthor | Min Joo Kim | - |
dc.contributor.googleauthor | Young Suk Jo | - |
dc.contributor.googleauthor | Min Ho Shong | - |
dc.contributor.googleauthor | Sung-Soo Koong | - |
dc.contributor.googleauthor | Jong Ryeal Hahm | - |
dc.contributor.googleauthor | Jung Hwa Jung | - |
dc.contributor.googleauthor | Ka Hee Yi | - |
dc.identifier.doi | 10.1210/jc.2016-2287 | - |
dc.contributor.localId | A03853 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 27732329 | - |
dc.identifier.url | https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-2287 | - |
dc.contributor.alternativeName | Jo, Young Suk | - |
dc.contributor.affiliatedAuthor | Jo, Young Suk | - |
dc.citation.title | Journal of Clinical Endocrinology & Metabolism | - |
dc.citation.volume | 102 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 625 | - |
dc.citation.endPage | 633 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.102(2) : 625-633, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42192 | - |
dc.type.rims | ART | - |
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