Cited 28 times in
Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study
DC Field | Value | Language |
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dc.contributor.author | 김승일 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 서다혜 | - |
dc.contributor.author | 손주혁 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2017-11-02T08:13:17Z | - |
dc.date.available | 2017-11-02T08:13:17Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0959-8049 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154215 | - |
dc.description.abstract | BACKGROUND: Management of metabolic complications of long-term adjuvant endocrine therapy in early breast cancer remained an unmet need. We aimed to compare the effects of tamoxifen (TMX) and aromatase inhibitors (AIs) on the risk of fatty liver in conjunction with longitudinal changes in the serum lipid parameters. METHODS: Among 1203 subjects who were taking adjuvant TMX or AI (anastrozole or letrozole) without fatty liver at baseline, those taking TMX or AI were 1:1 matched on the propensity score. The primary outcome was newly developed fatty liver detected on annual liver ultrasonography. RESULTS: Among 328 matched subjects (mean age 53.5 years, body mass index 22.9 kg/m2), 62 cases of fatty liver in the TMX group and 41 cases in the AI group were detected in a total of 987.4 person-years. The incidence rate of fatty liver was higher in the TMX group than in the AI group (128.7 versus 81.1 per 1000 person-years, P = 0.021), particularly within the first 2 years of therapy. TMX was associated with an increased 5-year risk of newly developed fatty liver (adjusted hazard ratio 1.61, P = 0.030) compared with AI independent of obesity and cholesterol level. Subjects who developed fatty liver had higher triglycerides (TGs) and lower high-density lipoprotein cholesterol (HDL-C) level at baseline than those without, which was sustained during follow-up despite the serum cholesterol-lowering effect of TMX. CONCLUSIONS: TMX independently increased the 5-year risk of newly developed fatty liver compared with AI in postmenopausal women with early breast cancer. Our findings suggest the need for considering the risk of fatty liver as a different adverse event profile between AI and TMX, particularly in patients with obesity, high TGs and low HDL-C. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Ltd | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents, Hormonal/adverse effects* | - |
dc.subject.MESH | Aromatase Inhibitors/adverse effects* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Chemotherapy, Adjuvant/adverse effects | - |
dc.subject.MESH | Fatty Liver/chemically induced* | - |
dc.subject.MESH | Fatty Liver/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Lipids/blood* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nitriles/adverse effects | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tamoxifen/adverse effects* | - |
dc.subject.MESH | Triazoles/adverse effects | - |
dc.title | Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Han Gyul Yoon | - |
dc.contributor.googleauthor | Da Hea Seo | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Seung Il Kim | - |
dc.contributor.googleauthor | Joo Hyuk Sohn | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1016/j.ejca.2017.05.002 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A04756 | - |
dc.contributor.localId | A01995 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A04388 | - |
dc.contributor.localId | A00658 | - |
dc.relation.journalcode | J00809 | - |
dc.identifier.eissn | 1879-0852 | - |
dc.identifier.pmid | 28651157 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0959804917309346 | - |
dc.subject.keyword | Adjuvant endocrine therapy | - |
dc.subject.keyword | Anastrozole | - |
dc.subject.keyword | Hepatic steatosis | - |
dc.subject.keyword | High-density lipoprotein cholesterol | - |
dc.subject.keyword | Letrozole | - |
dc.subject.keyword | Tamoxifen | - |
dc.subject.keyword | Triglyceride | - |
dc.contributor.alternativeName | Kim, Seung Il | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Seo, D. | - |
dc.contributor.alternativeName | Sohn, Joo Hyuk | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Hong, Nam Ki | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Seo, D. | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyuk | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Hong, Namki | - |
dc.contributor.affiliatedAuthor | Kim, Seung Il | - |
dc.citation.title | European Journal of Cancer | - |
dc.citation.volume | 82 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 114 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CANCER, Vol.82 : 103-114, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42183 | - |
dc.type.rims | ART | - |
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