Cited 11 times in
Risk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 박용은 | - |
dc.contributor.author | 박지혜 | - |
dc.contributor.author | 이윤지 | - |
dc.contributor.author | 이현정 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2017-11-02T08:12:57Z | - |
dc.date.available | 2017-11-02T08:12:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0179-1958 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154210 | - |
dc.description.abstract | BACKGROUND: Intestinal Behçet's disease (BD) can cause acute lower gastrointestinal bleeding, which is sometimes fatal. AIM: We aimed to identify the risk factors and outcomes of acute lower gastrointestinal bleeding and factors associated with rebleeding in intestinal BD patients. METHODS: Of the total of 588 intestinal BD patients, we retrospectively reviewed the medical records of 66 (11.2%) patients with acute lower gastrointestinal bleeding and compared them with those of 132 matched patients without bleeding. RESULTS: The baseline characteristics were comparable between the bleeding group (n = 66) and the non-bleeding group (n = 132). On multivariate analysis, the independent factors significantly associated with lower gastrointestinal bleeding were older age (>52 years) (hazard ratio [HR] 2.2, 95% confidence interval [CI] 1.058-4.684, p = 0.035) and a nodular ulcer margin (HR 7.1, 95% CI 2.084-24.189, p = 0.002). Rebleeding occurred in 23 patients (34.8%). Female patients (p = 0.044) and those with previous use of corticosteroids or azathioprine (p = 0.034) were more likely to develop rebleeding. On multivariate analysis, only use of steroids or azathioprine was significantly associated with rebleeding (HR 3.2, 95% CI 1.070-9.462, p = 0.037). CONCLUSIONS: Age >52 years and the presence of a nodular margin of the ulcer were found to be related to increased risk of bleeding in patients with intestinal BD. Rebleeding is not uncommon and not effectively prevented with currently available medications. Further studies are warranted to identify effective measures to decrease rebleeding in intestinal BD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Behcet Syndrome/complications* | - |
dc.subject.MESH | Behcet Syndrome/epidemiology | - |
dc.subject.MESH | Behcet Syndrome/therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/complications* | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/epidemiology | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intestinal Diseases/complications* | - |
dc.subject.MESH | Intestinal Diseases/epidemiology | - |
dc.subject.MESH | Intestinal Diseases/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Risk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behçet's disease | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jihye Park | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Yong Eun Park | - |
dc.contributor.googleauthor | Yoon Jee Lee | - |
dc.contributor.googleauthor | Hyun Jung Lee | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.1007/s00384-016-2728-x | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A04571 | - |
dc.contributor.localId | A04575 | - |
dc.contributor.localId | A05166 | - |
dc.contributor.localId | A03295 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01100 | - |
dc.identifier.eissn | 1432-1262 | - |
dc.identifier.pmid | 27924367 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00384-016-2728-x | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | Gastrointestinal hemorrhage | - |
dc.subject.keyword | Outcome | - |
dc.subject.keyword | Rebleeding | - |
dc.subject.keyword | Risk factor | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Park, Yong Eun | - |
dc.contributor.alternativeName | Park, Ji Hye | - |
dc.contributor.alternativeName | Lee, Yoon Jee | - |
dc.contributor.alternativeName | Lee, Hyun Jung | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Park, Yong Eun | - |
dc.contributor.affiliatedAuthor | Park, Ji Hye | - |
dc.contributor.affiliatedAuthor | Lee, Yoon Jee | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.citation.title | International Journal of Colorectal Disease | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 745 | - |
dc.citation.endPage | 751 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol.32(5) : 745-751, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42179 | - |
dc.type.rims | ART | - |
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