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Risk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behçet's disease

DC Field Value Language
dc.contributor.author천재희-
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author박용은-
dc.contributor.author박지혜-
dc.contributor.author이윤지-
dc.contributor.author이현정-
dc.contributor.author홍성필-
dc.date.accessioned2017-11-02T08:12:57Z-
dc.date.available2017-11-02T08:12:57Z-
dc.date.issued2017-
dc.identifier.issn0179-1958-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154210-
dc.description.abstractBACKGROUND: Intestinal Behçet's disease (BD) can cause acute lower gastrointestinal bleeding, which is sometimes fatal. AIM: We aimed to identify the risk factors and outcomes of acute lower gastrointestinal bleeding and factors associated with rebleeding in intestinal BD patients. METHODS: Of the total of 588 intestinal BD patients, we retrospectively reviewed the medical records of 66 (11.2%) patients with acute lower gastrointestinal bleeding and compared them with those of 132 matched patients without bleeding. RESULTS: The baseline characteristics were comparable between the bleeding group (n = 66) and the non-bleeding group (n = 132). On multivariate analysis, the independent factors significantly associated with lower gastrointestinal bleeding were older age (>52 years) (hazard ratio [HR] 2.2, 95% confidence interval [CI] 1.058-4.684, p = 0.035) and a nodular ulcer margin (HR 7.1, 95% CI 2.084-24.189, p = 0.002). Rebleeding occurred in 23 patients (34.8%). Female patients (p = 0.044) and those with previous use of corticosteroids or azathioprine (p = 0.034) were more likely to develop rebleeding. On multivariate analysis, only use of steroids or azathioprine was significantly associated with rebleeding (HR 3.2, 95% CI 1.070-9.462, p = 0.037). CONCLUSIONS: Age >52 years and the presence of a nodular margin of the ulcer were found to be related to increased risk of bleeding in patients with intestinal BD. Rebleeding is not uncommon and not effectively prevented with currently available medications. Further studies are warranted to identify effective measures to decrease rebleeding in intestinal BD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF COLORECTAL DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHBehcet Syndrome/complications*-
dc.subject.MESHBehcet Syndrome/epidemiology-
dc.subject.MESHBehcet Syndrome/therapy*-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Hemorrhage/complications*-
dc.subject.MESHGastrointestinal Hemorrhage/epidemiology-
dc.subject.MESHGastrointestinal Hemorrhage/therapy*-
dc.subject.MESHHumans-
dc.subject.MESHIntestinal Diseases/complications*-
dc.subject.MESHIntestinal Diseases/epidemiology-
dc.subject.MESHIntestinal Diseases/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrevalence-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.titleRisk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behçet's disease-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJihye Park-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorYong Eun Park-
dc.contributor.googleauthorYoon Jee Lee-
dc.contributor.googleauthorHyun Jung Lee-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.1007/s00384-016-2728-x-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01539-
dc.contributor.localIdA04571-
dc.contributor.localIdA04575-
dc.contributor.localIdA05166-
dc.contributor.localIdA03295-
dc.contributor.localIdA04404-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ01100-
dc.identifier.eissn1432-1262-
dc.identifier.pmid27924367-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00384-016-2728-x-
dc.subject.keywordBehçet’s disease-
dc.subject.keywordGastrointestinal hemorrhage-
dc.subject.keywordOutcome-
dc.subject.keywordRebleeding-
dc.subject.keywordRisk factor-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNamePark, Yong Eun-
dc.contributor.alternativeNamePark, Ji Hye-
dc.contributor.alternativeNameLee, Yoon Jee-
dc.contributor.alternativeNameLee, Hyun Jung-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.contributor.affiliatedAuthorPark, Yong Eun-
dc.contributor.affiliatedAuthorPark, Ji Hye-
dc.contributor.affiliatedAuthorLee, Yoon Jee-
dc.contributor.affiliatedAuthorLee, Hyun Jung-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.titleInternational Journal of Colorectal Disease-
dc.citation.volume32-
dc.citation.number5-
dc.citation.startPage745-
dc.citation.endPage751-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol.32(5) : 745-751, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42179-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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